Ontogeny of region-specific sex differences in androgen receptor messenger ribonucleic acid expression in the rat forebrain

Endocrinology
M D McAbee, L L DonCarlos

Abstract

Testosterone and its metabolites are the principal gonadal hormones responsible for sexual differentiation of the brain. However, the relative roles of the androgen receptor (AR) vs. the estrogen receptor in specific aspects of this process remain unclear due to the intracellular metabolism of testosterone to active androgenic and estrogenic compounds. In this study, we used an 35S-labeled riboprobe and in situ hybridization to analyze steady state, relative levels of AR messenger RNA (mRNA) expression in the developing bed nucleus of the stria terminalis, medial preoptic area, and lateral septum, as well as the ventromedial and arcuate nuclei of the hypothalamus. Each area was examined on embryonic day 20 and postnatal days 0, 4, 10, and 20 to produce a developmental profile of AR mRNA expression. AR mRNA hybridization was present on embryonic day 20 in all areas analyzed. In addition, AR mRNA expression increased throughout the perinatal period in all areas examined in both males and females. However, between postnatal days 4 and 10, sharp increases in AR mRNA expression in the principal portion of the bed nucleus of the stria terminalis and the medial preoptic area occurred in the male that were not paralleled in the female....Continue Reading

References

Apr 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·C E Roselli, T A Fasasi
May 1, 1990·Endocrine Reviews·M A Carson-JuricaB W O'Malley
May 14, 1990·Brain Research·C A Lisciotto, J I Morrell
Feb 1, 1988·Trends in Neurosciences·M J Meaney
Feb 10, 1989·Cell·M Beato
May 1, 1987·Brain Research·M C Diamond
Sep 15, 1973·The Journal of Comparative Neurology·D Pfaff, M Keiner
Mar 20, 1981·Science·N J MacLusky, F Naftolin
Jan 1, 1984·Annual Review of Neuroscience·A P Arnold, R A Gorski
Jun 1, 1981·Hormones and Behavior·M J Meaney, J Stewart
Aug 1, 1981·Brain Research·C C Vito, T O Fox
Aug 25, 1980·Brain Research·I LieberburgB S McEwen
Jun 17, 1994·Brain Research. Developmental Brain Research·L L DonCarlos, R J Handa
Jan 1, 1994·Annual Review of Biochemistry·M J Tsai, B W O'Malley
Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·C E Roselli, J A Resko
Jul 1, 1996·Brain Research. Molecular Brain Research·R J HandaG Hejna
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Pfaff

❮ Previous
Next ❯

Citations

Jan 24, 2009·Biology of Reproduction·Lori M GortonRuth I Wood
Nov 19, 2002·Neuroscience Letters·Keisuke YoneharaMasugi Nishihara
Sep 5, 2002·The Journal of Comparative Neurology·Daniel García-OvejeroLydia L Doncarlos
Jul 10, 2012·Hormones and Behavior·Jill M WeathingtonBradley M Cooke
Jun 24, 2009·Psychoneuroendocrinology·Anthony P Auger, Heather M Jessen
Apr 12, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Paola Negri-CesiFabio Celotti
Apr 15, 2008·Hormones and Behavior·Cynthia L Jordan, Lydia Doncarlos
Apr 1, 2008·Hormones and Behavior·Eileen M FoeckingJon E Levine
Oct 24, 2015·Neuroscience Letters·Shunji YamadaMitsuhiro Kawata
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Daniel A GorelickMarnie E Halpern
Jul 14, 2012·The Journal of Comparative Neurology·Jinyan Cao, Heather B Patisaul
May 15, 2012·The Journal of Comparative Neurology·Ryan T JohnsonCynthia L Jordan
Dec 8, 2004·Experimental Gerontology·Vladimir K PatchevAlexandre V Patchev
Nov 29, 2005·Neuroscience·L L DonCarlosL-M Garcia-Segura
Dec 1, 2010·Drug and Alcohol Dependence·Tom HildebrandtDonald W Pfaff
Sep 12, 2012·General and Comparative Endocrinology·Jorgelina VarayoudJorge Guillermo Ramos
Oct 5, 2012·Biology of Reproduction·Deena M WalkerAndrea C Gore
Sep 6, 2000·The Journal of Comparative Neurology·A Fernández-GuastiD F Swaab
Apr 30, 2003·The Journal of Comparative Neurology·Guibao GuRichard B Simerly
Nov 6, 2018·Anatomical Science International·Yousuke Tsuneoka
May 10, 2005·The Journal of Comparative Neurology·John A MorrisS Marc Breedlove
Oct 18, 2005·The Journal of Comparative Neurology·Betty LorenzLydia L DonCarlos
Dec 21, 2004·Journal of Neurochemistry·T U MarronA Poletti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.