Ontogeny of serotonin and serotonin2A receptors in rat auditory cortex.

Hearing Research
G J BasuraPaul B Manis

Abstract

Maturation of the mammalian cerebral cortex is, in part, dependent upon multiple coordinated afferent neurotransmitter systems and receptor-mediated cellular linkages during early postnatal development. Given that serotonin (5-HT) is one such system, the present study was designed to specifically evaluate 5-HT tissue content as well as 5-HT(2A) receptor protein levels within the developing auditory cortex (AC). Using high performance liquid chromatography (HPLC), 5-HT and the metabolite, 5-hydroxyindoleacetic acid (5-HIAA), was measured in isolated AC, which demonstrated a developmental dynamic, reaching young adult levels early during the second week of postnatal development. Radioligand binding of 5-HT(2A) receptors with the 5-HT(2A/2C) receptor agonist, (125)I-DOI ((+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl; in the presence of SB206553, a selective 5-HT(2C) receptor antagonist, also demonstrated a developmental trend, whereby receptor protein levels reached young adult levels at the end of the first postnatal week (P8), significantly increased at P10 and at P17, and decreased back to levels not significantly different from P8 thereafter. Immunocytochemical labeling of 5-HT(2A) receptors and confocal microscopy r...Continue Reading

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Citations

Oct 5, 2010·Journal of Neurophysiology·Deepti RaoPaul B Manis
Dec 29, 2010·Hearing Research·L M Hurley, I C Hall
Feb 22, 2011·Cell·Franck OuryGerard Karsenty
Oct 8, 2014·International Journal of Audiology·Karolina K CharaziakJonathan H Siegel
Oct 19, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ankit SoodVidita A Vaidya
May 14, 2020·Journal of Neurophysiology·Tyler R SizemoreAndrew M Dacks
Jan 14, 2017·Frontiers in Neural Circuits·Catherine Pérez-ValenzuelaAlexies Dagnino-Subiabre
Sep 18, 2020·Canadian Journal of Physiology and Pharmacology·Raquel de Medeiros Maia CamposRaul Manhães-de-Castro

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