Ontogeny of serum insulin-like growth factor binding proteins in the rat.

Endocrinology
S M DonovanR G Rosenfeld

Abstract

Insulin-like growth factors (IGF-I and -II) are peptide growth factors that may be important for neonatal development. Specific high affinity IGF binding proteins (BPs) have been characterized in serum and extracellular fluids. The major serum binding complex in the adult has an apparent Mr of 150 K, while the predominant BP in the neonate is approximately 30 K. In the rat, the transition from the neonatal BP to the adult form occurs during the third postnatal week, concomitant with an increase in serum IGF-I and a decrease in serum IGF-II concentrations. Using specific RIAs and Western ligand blot analyses we have characterized the changes in serum IGF and IGF BPs, respectively, during the early postnatal period. Seven BPs were identified in serum with apparent Mr values of 42, 41, 40, 38, 28, 26, and 22 K. After deglycosylation, the 42, 41, 40, and 38 K BPs were reduced to two bands with apparent Mr values of 35 and 32 K, while the 28, 26, and 22 K BP were unchanged. In the neonate, the 28, 26, and 22 K BPs were present, with the 28 K BP in highest concentration. With increasing age, the 28 K BP decreased and the 42, 41, 40, and 38 K BPs appeared at approximately 19 days of age. Comparison of Western ligand blots of neonatal ...Continue Reading

Citations

Nov 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T MoriwakeB Ecarot
Oct 21, 1991·Brain Research. Developmental Brain Research·S PonsI Torres-Aleman
Feb 24, 1994·Regulatory Peptides·O P ChaurasiaE R Seidel
Dec 21, 1990·Molecular and Cellular Endocrinology·J M Luo, L J Murphy
May 1, 1993·Molecular and Cellular Endocrinology·C Y LeeF A Simmen
Jul 1, 1994·Comparative Biochemistry and Physiology. Biochemistry and Molecular Biology·K A KampmanM E White
Sep 18, 2003·Placenta·Abigail L Fowden
Aug 26, 1998·The Journal of Laboratory and Clinical Medicine·M T TchorzewskiJ W Harmon
Dec 30, 1992·Biochemical and Biophysical Research Communications·C G Prosser, R D McLaren
Jan 1, 1997·Neurobiology of Disease·E L FeldmanJ W Russell
Nov 2, 1999·Biochemical and Biophysical Research Communications·P M ArnoldB W Festoff
Feb 12, 1998·The American Journal of Physiology·T J WesterD G Burrin
Nov 30, 2000·American Journal of Physiology. Renal Physiology·A De La PuenteA M Pascual-Leone
Nov 14, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·C A ShoubridgeL C Read
Oct 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·S RamosA M Pascual-Leone
Aug 7, 2003·American Journal of Physiology. Endocrinology and Metabolism·Ilham El-KhattabiBrigitte Reusens
Mar 1, 1991·The American Journal of Physiology·S D ChernausekS B Hoath
Aug 1, 1996·The American Journal of Physiology·L GoyaA M Pascual-Leone
Mar 17, 2018·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Charles CaiKay D Beharry
Aug 1, 1992·The American Journal of Physiology·H OlanrewajuE R Seidel

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.