PMID: 9442348Jan 27, 1998Paper

Ontogeny of sex differences in the mammalian hypothalamus and preoptic area

Cellular and Molecular Neurobiology
S Tobet, I Hanna

Abstract

1. There are numerous sites in the nervous system where steroid hormones dramatically influence development. Increasing interest in mechanisms in neural development is providing avenues for understanding how gonadal steroids alter the ontogeny of these regions during sexual differentiation. 2. An increasing number of researchers are examining effects of gonadal steroids on neurite outgrowth, cell differentiation, cell death, cell migration, and synaptogenesis. The interrelated timing of these events may be a key aspect influenced by gonadal steroids throughout development. 3. The preoptic area and hypothalamus are characteristically heterogeneous in terms of cell type (e.g., different neuropeptides) and cell derivation. Perhaps a major reason for the ontogeny of sexual differences in the preoptic area and hypothalamus lies in the convergence of many different cell types from diverse sources (i.e., proliferative zones surrounding the lateral and third ventricles, and the olfactory placodes) that can be influenced in an interactive manner by gonadal steroid mechanisms. 4. The characterization of multiple mechanisms (e.g., trophic, migratory, apoptotic, fate, etc.,) that contribute to permanent changes in brain structure and ultim...Continue Reading

Citations

Oct 8, 1999·Journal of Neurobiology·R G HendersonS A Tobet
Aug 24, 2002·The European Journal of Neuroscience·Stuart A Tobet
Feb 18, 2011·Social Psychiatry and Psychiatric Epidemiology·Michael AnastarioJill M Goldstein
Jul 30, 2014·Psychological Medicine·J M GoldsteinS L Buka
Aug 13, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emily G JacobsJill M Goldstein
Feb 3, 2005·Nutritional Neuroscience·João Esmeraldo Frota MendonçaBelmira Lara da Silveira Andrade Da Costa
Feb 12, 2009·Journal of Neuroendocrinology·S TobetK McClellan
Jul 20, 2016·Clinical Science·Neza Grgurevic, Gregor Majdic
Jul 22, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jill M GoldsteinRobert J Handa
Mar 11, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ronald G GarciaJill M Goldstein
May 17, 2002·Journal of Applied Physiology·Yijiang Shi, Evelyn H Schlenker
Oct 18, 2005·The Journal of Comparative Neurology·Betty LorenzLydia L DonCarlos
Sep 5, 2007·The European Journal of Neuroscience·John Gabriel KnollStuart A Tobet
Jul 2, 2014·Frontiers in Neuroscience·Daniel A LeeSeth Blackshaw
Aug 28, 2007·Frontiers in Neuroendocrinology·Julie Bakker, Michael J Baum
Nov 10, 2009·Neuroscience Research·Ritsuko Ohtani-KanekoChiho Watanabe
Mar 2, 2010·Journal of Chemical Neuroanatomy·Nicoletta AsteNoboru Saito

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