Ontogeny of thyrotropin-releasing hormone gene expression in the rat diencephalon

Neuroendocrinology
J M Burgunder, T Taylor

Abstract

The development of thyrotropin-releasing hormone (TRH) gene expression in the rat diencephalon was studied using in situ hybridization histochemistry. The first neurons expressing the TRH gene were found on gestational day 14 (E14) in the lateral hypothalamus, shortly after completion of their last cell division. On E15 and E16, additional labeled cells appeared medially in the developing dorsomedial and paraventricular nuclei, respectively, followed on E17 by cells in the preoptic area. The number of labeled cells in the hypothalamus continued to increase during the last part of gestation. At birth, TRH mRNA neurons were present in all the locations seen in the adult hypothalamus. During the first week of life, the labeling intensity and number of neurons containing TRH mRNA continued to increase at the locations described above. TRH mRNA was not detected in the reticular thalamic nucleus until the 7th postnatal day when some labeled cells appeared in its dorsocaudal portion. Over the next 10 days, the number of labeled cells and the intensity of labeling in the thalamic reticular nucleus progressively increased. During the same period of time, only small changes in the number and intensity of labeled cells in the hypothalamus...Continue Reading

Citations

Jun 1, 1989·Cellular and Molecular Neurobiology·J M Burgunder, W S Young
Nov 19, 1991·Brain Research. Developmental Brain Research·Y OkamuraS Daikoku
Apr 24, 1992·Brain Research. Developmental Brain Research·M A VargasP Joseph-Bravo
Mar 18, 1994·Brain Research. Developmental Brain Research·J M Burgunder
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M KawataY Sano
Jul 20, 2002·Frontiers in Neuroendocrinology·Eleni A Markakis
Dec 31, 1997·Brain Research. Brain Research Reviews·E A Markakis, L W Swanson
Sep 15, 2001·Brain Research. Developmental Brain Research·L Pérez-MartínezP Joseph-Bravo
Dec 28, 1999·Journal of Chemical Neuroanatomy·J M BurgunderT Lauterburg
Sep 13, 2001·The European Journal of Neuroscience·M Guerra-CrespoL Pérez-Martínez
Jun 13, 2002·Environmental Health Perspectives·Kembra L Howdeshell
Dec 18, 2013·Brain Structure & Function·Nicanor Morales-DelgadoCarmen Díaz
May 22, 2001·The European Journal of Neuroscience·F BrischouxP Y Risold
Feb 9, 2013·Endocrinology and Metabolism Clinics of North America·Sophie M SteculorumJens C Brüning
Apr 14, 2010·Molecular and Cellular Endocrinology·Eva SzarekPaul Thomas
Sep 22, 2009·Brain Research·Alfonso Carreón-RodríguezLeonor Pérez-Martínez
Nov 23, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Osama M AhmedR G Ahmed
Mar 1, 1992·Trends in Endocrinology and Metabolism : TEM·A Tixier-Vidal, A Faivre-Bauman
Feb 28, 2004·Molecular Endocrinology·Eleni GoshuChen-Ming Fan
Nov 6, 2010·Endocrine Reviews·Floor Remmers, Henriette A Delemarre-van de Waal
Mar 29, 2008·Endocrinology·Floor RemmersHenriette A Delemarre-van de Waal
Aug 16, 2016·Reviews in Endocrine & Metabolic Disorders·Patricia Joseph-BravoJean-Louis Charli
Oct 1, 1992·The Journal of Comparative Neurology·J M Burgunder, W S Young

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.