PMID: 18407080Mar 1, 1992Paper

Ontogeny of thyrotropin-releasing hormone biosynthesis and release in hypothalamic neurons

Trends in Endocrinology and Metabolism : TEM
A Tixier-Vidal, A Faivre-Bauman

Abstract

Thyrotropin-releasing hormone (TRH) is expressed at early postmitotic stages of hypothalamic neuron development, in the mouse and rat, as revealed by the presence of the mature peptide, of pro-TRH mRNAs, and of large precursor forms. This indicates a coordinate expression of several genes encoding, respectively, pro-TRH, its processing enzymes, and the cell machinery for intracellular transport, sorting, and release of TRH. During development, an acceleration of pro-TRH processing is revealed by an increased proportion of the mature peptide. This is correlated with changes in the respective distribution of pro-TRH and TRH along neurites and the ontogenesis of neurosecretory granules.

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Citations

Sep 15, 1994·Annals of the New York Academy of Sciences·A Tixier-Vidal
Apr 29, 1998·Journal of Medical Ethics·S Smith
Jul 2, 2009·Integrative Psychological & Behavioral Science·Zachary Beckstead
Oct 9, 2009·Journal of Evaluation in Clinical Practice·Joachim P Sturmberg, Paul Cilliers
Feb 13, 2010·Sociology of Health & Illness·Abigail T Brooks
Dec 23, 2006·Sociology of Health & Illness·Helen Busby
Aug 11, 2010·Tropical Animal Health and Production·Ina-Salwany Mohd YasinEffendy Abd Wahid Mohd

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