Ontological evaluation of transcriptional differences between sperm of infertile males and fertile donors using microarray analysis.

Journal of Assisted Reproduction and Genetics
Sandra García-HerreroMarcos Meseguer

Abstract

To catalogue Gene Ontology terms in the sperm of infertile human males vs. donors of proven fertility by analyzing five samples from each of the two groups (five aliquots from fresh sperm and five post-swim-up). Microarray technology was employed to study the mRNA profile of both fresh and post-swim-up pooled samples from infertile males and donors. Genes that were differentially expressed in the two populations and expressed in only one of two were analyzed to determine the gene products in terms of their associated Gene Ontology terms. Each group presented a different number and pattern of Gene Ontology terms. We found differences in Gene Ontology terms between the two groups. These differences could potentially be employed to establish markers of fertility success and to identify cellular processes and complex systems related with male infertility.

Associated Clinical Trials

Aug 28, 2015·Elena Sellés Soriano

References

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Dec 17, 2008·Reproductive Biomedicine Online·Nicolás GarridoMarcos Meseguer

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Citations

Jun 15, 2011·Journal of Assisted Reproduction and Genetics·Igor CrhaMichal Pohanka
Feb 8, 2011·Asian Journal of Andrology·Michael C HannHelen G Tempest
Feb 23, 2012·Human Reproduction·Meritxell JodarRafael Oliva
Jul 17, 2013·Human Reproduction Update·Meritxell JodarUNKNOWN Reproductive Medicine Network
Sep 30, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Graham D JohnsonStephen A Krawetz
Sep 6, 2014·Journal of Human Reproductive Sciences·Rocío Rivera EgeaAlex C Varghese
Mar 19, 2013·Fertility and Sterility·Nicolás GarridoMarcos Meseguer
Dec 3, 2010·Reproductive Biomedicine Online·Sandra García-HerreroMarcos Meseguer
Mar 14, 2020·BMC Genetics·Flor-Anita CorredorNick V L Serão
Aug 15, 2018·Journal of Assisted Reproduction and Genetics·Rocio Rivera-EgeaFrancisco Dominguez
Apr 10, 2021·Journal of Assisted Reproduction and Genetics·Rocio Rivera-EgeaFrancisco Dominguez
Oct 9, 2021·Human Reproduction Update·Joana SantiagoMargarida Fardilha

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