Ontological model of multi-agent Smart-system for predicting drug properties based on modified algorithms of artificial immune systems.

Theoretical Biology & Medical Modelling
Galina Samigulina, Zarina Samigulina

Abstract

Currently, due to the huge progress in the field of information technologies and computer equipment, it is important to use modern approaches of artificial intelligence in order to process extensive chemical information at creating new drugs with desired properties. The interdisciplinary of research creates additional difficulties in creating new drugs. Currently, there are no universal algorithms and software for predicting the "structure-property" dependence of drug compounds that can take into account the needs of specialists in this field. In this regard, the development of a modern Smart-system based on the promising bio-inspired approach of artificial immune systems for predicting the structure-property dependence of drug compounds is relevant. The aim of this work is to develop a multi-agent Smart-system for predicting the "structure-property" dependence of drug compounds using the ontological approach and modified algorithms of artificial immune systems using the example of drug compounds of the sulfonamide group. The proposed system makes it possible to increase the accuracy of prediction models of the "structure-property" dependence, to reduce the time and financial costs for obtaining candidate drug compounds. During...Continue Reading

References

Jan 30, 2010·European Journal of Medicinal Chemistry·Rachid DarnagDriss Cherqaoui
Mar 10, 2017·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Kobra ZareiMonire Ahmadi
Sep 6, 2017·Journal of Chemical Information and Modeling·Yuting XuVladimir Svetnik
Jun 12, 2018·Combinatorial Chemistry & High Throughput Screening·Hossein AtabatiHamid Reza Zare-Mehrjardi
Jun 25, 2018·Drug Discovery Today·Fahimeh GhasemiHoracio Pérez-Sánchez
Oct 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gerhard Hessler, Karl-Heinz Baringhaus
Oct 20, 2018·Expert Opinion on Drug Discovery·Verena Schöning, Felix Hammann
Sep 26, 2019·Frontiers in Neuroscience·Keiko Morimoto, Kazunori Nakajima

❮ Previous
Next ❯

Software Mentioned

Dragon
Protégé
CLONALG
CLONALG1
HyperChem
AIS
CLONCLAS
CLONALG2
AIRS
Rapid Miner

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

IEEE Transactions on Systems, Man, and Cybernetics. Part B, Cybernetics : a Publication of the IEEE Systems, Man, and Cybernetics Society
Philippe De Wilde, G Briscoe
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Peng ShangChengtao Wang
© 2021 Meta ULC. All rights reserved