Ontology and Function of Fibroblast-Like and Macrophage-Like Synoviocytes: How Do They Talk to Each Other and Can They Be Targeted for Rheumatoid Arthritis Therapy?

Frontiers in Immunology
Jiajie TuWei Wei

Abstract

Fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS) are the two main cellular components of the synovium. It has been widely reported that FLS and MLS play essential roles in the joint pathology of rheumatoid arthritis (RA). Although various studies have analyzed both human and animal tissues and have shown that both cell types are involved in different stages of RA, ontology, and specific functions of both cell populations and their interactions are not well understood. In this review, we will summarize recent research on FLS and MLS in RA and focus on the development and function of two predominant synovial cell types. In addition, we will discuss the communication between FLS or MLS and highlight potential treatments for RA that involve synoviocytes.

References

Jan 1, 1976·Annals of the New York Academy of Sciences·R van Furth
Apr 19, 2000·Archives of Histology and Cytology·T IwanagaK Nozawa-Inoue
Jul 12, 2002·Arthritis Research·Danielle Burger, Jean-Michel Dayer
Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Harris PerlmanRichard M Pope
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kimihisa IchikawaTong Zhou
Dec 18, 2003·Rheumatology·M D Smith, J G Walker
Mar 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomoyuki InoueGary S Firestein
May 12, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Adam MorMichael H Pillinger
Mar 29, 2006·Rheumatology·L C HuberT Pap
Apr 4, 2006·Current Opinion in Rheumatology·Joanna StanczykSteffen Gay
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anneke J van VuurenTheo Thepen
Jul 6, 2006·Arthritis Research & Therapy·George Nuki, Peter A Simkin
May 26, 2007·Nature Reviews. Immunology·Iain B McInnes, Georg Schett
Oct 3, 2009·Nature Reviews. Rheumatology·Ann L CornishIan P Wicks
Mar 3, 2010·Immunological Reviews·Beatrix Bartok, Gary S Firestein
Sep 28, 2010·Lancet·David L ScottTom W J Huizinga
Feb 10, 2011·Arthritis and Rheumatism·Monica GumaMaripat Corr
May 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sook Kyung ChangMichael B Brenner
Aug 16, 2011·The American Journal of Pathology·Katja DenningerTord Labuda
Sep 25, 2012·Trends in Immunology·John A Hamilton, Adrian Achuthan
Dec 4, 2012·Rheumatology·Jean-Luc DavignonAlain Cantagrel
Dec 14, 2012·Annals of the Rheumatic Diseases·Gerd R BurmesterUNKNOWN EARTH Study Group
Feb 1, 2013·Arthritis Research & Therapy·Rowan S HardyHong Zhou
Feb 16, 2013·Cancer Cell·Giovanni GermanoPaola Allavena
Nov 13, 2013·Nature Reviews. Rheumatology·Gerd R BurmesterThomas Dörner

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Citations

May 22, 2019·Apoptosis : an International Journal on Programmed Cell Death·Palani Dinesh, MahaboobKhan Rasool
Sep 5, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Min Jeong Ji, Jeong Hee Hong
Sep 25, 2020·Journal of Cellular and Molecular Medicine·Peng ShenAmir Abbas Momtazi-Borojeni
Jan 16, 2020·Biomedicines·Andrei A DeviatkinAlexander N Lukashev
Jul 3, 2020·Clinical Rheumatology·Muzhe LiZhiwei Chen
Oct 4, 2018·Drug Delivery and Translational Research·Durga M S H ChandrupatlaGerrit Jansen
Nov 6, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xinming WangWei Wei
Dec 2, 2020·Cell Communication and Signaling : CCS·Noritaka Saeki, Yuuki Imai
Jul 21, 2021·Inflammopharmacology·Ehsan NourbakhshFarnoosh Ebrahimzadeh
Aug 21, 2021·Drug Delivery and Translational Research·Allen B Tu, Jamal S Lewis
Oct 16, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Gang ZhaoDong Wang

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Software Mentioned

FLS
MLS

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