Ontology application and use at the ENCODE DCC

Database : the Journal of Biological Databases and Curation
Venkat S MalladiEurie L Hong

Abstract

The Encyclopedia of DNA elements (ENCODE) project is an ongoing collaborative effort to create a catalog of genomic annotations. To date, the project has generated over 4000 experiments across more than 350 cell lines and tissues using a wide array of experimental techniques to study the chromatin structure, regulatory network and transcriptional landscape of the Homo sapiens and Mus musculus genomes. All ENCODE experimental data, metadata and associated computational analyses are submitted to the ENCODE Data Coordination Center (DCC) for validation, tracking, storage and distribution to community resources and the scientific community. As the volume of data increases, the organization of experimental details becomes increasingly complicated and demands careful curation to identify related experiments. Here, we describe the ENCODE DCC's use of ontologies to standardize experimental metadata. We discuss how ontologies, when used to annotate metadata, provide improved searching capabilities and facilitate the ability to find connections within a set of experiments. Additionally, we provide examples of how ontologies are used to annotate ENCODE metadata and how the annotations can be identified via ontology-driven searches at the ...Continue Reading

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Nov 4, 2015·Nucleic Acids Research·Cricket A SloanJ Michael Cherry
Feb 28, 2016·Trends in Plant Science·Elzbieta SarnowskaTomasz J Sarnowski
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Datasets Mentioned

BETA
GM12878

Methods Mentioned

BETA
MeDIP-seq
RNA-seq
iCLIP
immunoprecipitation
Biosamples

Software Mentioned

ENCODE
Biocurators
Protégé
Uberon
AmiGO
CL
FASTQ
EFO

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