ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

Nature Medicine
C HeiseD H Kirn

Abstract

The 55-kilodalton (kDa) protein from the E1B-region of adenovirus binds to and inactivates the p53 gene, which is mutated in half of human cancers. We have previously shown that the replication and cytopathogenicity of an E1B, 55-kDa gene-attenuated adenovirus, ONYX-015, is blocked by functional p53 in RKO and U20S carcinoma lines. We now report that normal human cells were highly resistant to ONYX-015-mediated, replication-dependent cytolysis. In contrast, a wide range of human tumor cells, including numerous carcinoma lines with either mutant or normal p53 gene sequences (exons 5-9), were efficiently destroyed. Antitumoral efficacy was documented following intratumoral or intravenous administration of ONYX-015 to nude mouse-human tumor xenografts; efficacy with ONYX-015 plus chemotherapy (cisplatin, 5-fluorouracil) was significantly greater than with either agent alone.

References

Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M ScheffnerP M Howley
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N R RodriguesD P Lane
Oct 9, 1987·Science·E R FearonB Vogelstein
Feb 16, 1995·The New England Journal of Medicine·J A BrennanD Sidransky
Apr 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F ChangK Syrjänen
Nov 4, 1994·Science·S W LoweT Jacks
Jul 1, 1994·Scientific American·R K Jain
Apr 1, 1993·Genes & Development·M Debbas, E White
Oct 21, 1993·International Journal of Cancer. Journal International Du Cancer·R BrownS B Kaye
Jan 12, 1996·Science·R M Zinkernagel
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·J RothA J Levine

❮ Previous
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Citations

Oct 31, 2000·International Journal of Cancer. Journal International Du Cancer·H LeeJ H Kim
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·Z XuM W Büchler
Jun 13, 2001·Biochemical and Biophysical Research Communications·M OhashiM Omata
Aug 11, 2001·Bulletin of Mathematical Biology·J T WuL M Wein
Apr 16, 1998·Springer Seminars in Immunopathology·R V Sionov, Y Haupt
Feb 10, 1999·Medical Oncology·K G Wiman
Apr 24, 2009·Cancer Chemotherapy and Pharmacology·Zhu YuanXia Zhao
Sep 28, 1998·Cancer Chemotherapy and Pharmacology·M J Egorin
Mar 18, 2005·Journal of Mathematical Biology·Youshan Tao, Qian Guo
Mar 5, 2009·Apoptosis : an International Journal on Programmed Cell Death·Chao Lu, Wafik S El-Deiry
Mar 24, 2005·Cancer Metastasis Reviews·Kevin J HarringtonHardev S Pandha
Apr 25, 2006·Journal of Biomedical Science·Lih-Hwa Hwang
Oct 24, 2002·Current Treatment Options in Oncology·Stephen B Tatter
Feb 22, 2003·Current Treatment Options in Oncology·Samir N Khleif
Jan 26, 2008·Advances in Medical Sciences·H E Blum
Jun 24, 2004·Bulletin of Mathematical Biology·Joseph T WuLawrence M Wein
May 18, 2004·Cancer Treatment Reviews·John D ChesterAndrew S Protheroe
Jun 30, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kaveh Asadi-Moghaddam, E Antonio Chiocca
Sep 26, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Martine L M LamfersE Antonio Chiocca
May 16, 2000·Biochemical Pharmacology·D F Ranney
Sep 4, 1999·Urology·R Rodriguez, J W Simons
Jul 27, 2001·Molecular Aspects of Medicine·G M Rubanyi
Jun 2, 1998·Lancet·D A Haber, E R Fearon
Apr 2, 2003·Pharmacology & Therapeutics·M G CastroP R Lowenstein
Mar 22, 2002·Journal of Virological Methods·Nikita Avvakumov, Joe S Mymryk
Feb 4, 1998·Trends in Genetics : TIG·K Helin, G Peters
Jul 21, 1999·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·K S FrederiksenH S Poulsen
Aug 10, 2002·Cancer Letters·Boyoung LeeHeuiran Lee
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·M PruschyS Bodis
Sep 2, 1998·Current Opinion in Immunology·M Barry, G McFadden
Aug 26, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H L McLeodJ Cassidy
Dec 14, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S B Kaye
Sep 25, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yosef Buganim, Varda Rotter
Jul 31, 2001·Surgical Oncology·C M HalloranE Costello
May 23, 2001·Critical Reviews in Oncology/hematology·E GalanisS J Russell
Mar 26, 2003·Seminars in Cancer Biology·Irina V LebedevaPaul B Fisher
Dec 14, 2002·The International Journal of Biochemistry & Cell Biology·Bruno SangroJesus Prieto
Aug 24, 2000·Molecular Medicine Today·E H ChangK B Bouker
Apr 28, 2001·Cytokine & Growth Factor Reviews·A E KoromilasG Matlashewski
Apr 28, 2001·Cytokine & Growth Factor Reviews·K L NormanP W Lee
Jul 20, 2002·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·John Nemunaitis, Casey Cunningham
Nov 10, 2006·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·R D Meng, W S El-Deiry
Mar 22, 2002·The Lancet Oncology·Lynda K HawkinsDavid Kirn
Oct 2, 2013·The Lancet Oncology·Malcolm K BrennerJuan F Vera

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