Oocyte donation to women of advanced reproductive age: pregnancy results and obstetrical outcomes in patients 45 years and older

Human Reproduction
M V SauerR A Lobo

Abstract

We analysed the results of oocyte donation to women of advanced reproductive age (> or = 45 years old) and followed their pregnancies through to delivery in order to assess obstetrical outcomes. Patients (n = 162) aged 45-59 years (mean +/- SD; 47.3 +/- 3.4 years) underwent 218 consecutive attempts to achieve pregnancy. Oocytes (16.2 +/- 7.2 per retrieval) were provided by donors < or = 35 years old. Cleaving embryos (8.2 +/- 4.8 zygotes/couple) were transferred transcervically (4.5 +/- 1.1 per embryo transfer) to recipients prescribed oral micronized oestradiol and intramuscular progesterone. Following oocyte aspiration there were six instances of non-fertilization (2.8%) and 212 embryo transfers. A total of 103 pregnancies was established for an overall pregnancy rate (PR) of 48.6%, which included 17 preclinical pregnancies, 12 spontaneous abortions, and 74 delivered pregnancies (clinical PR 40.6%; delivered PR 34.9%). Multiple gestations were frequent (n = 29; 39.2% of pregnancies) and included 20 twins, seven triplets, and two quadruplets. Two of the triplet and both of the quadruplet pregnancies underwent selective reduction to twins. Antenatal complications occurred in 28 women (37.8% of deliveries) and included preterm l...Continue Reading

Citations

Jan 13, 2004·Archives of Gynecology and Obstetrics·Rachana Chibber
May 29, 2004·Archives of Gynecology and Obstetrics·Giovanni ZanconatoMassimo Franchi
Mar 13, 1998·Fertility and Sterility·M V Sauer
Sep 23, 2003·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·I Blickstein
Apr 1, 1998·Trends in Ecology & Evolution·L S Forbes
Jun 1, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Stephen D KeayDavid J Cahill
Jun 8, 2012·Reproductive Biology and Endocrinology : RB&E·Dominic StoopPaul Devroey
Jan 1, 2009·Reproductive Health·Joke M SchutteUNKNOWN Dutch Maternal Mortality Committee
Oct 10, 2001·Human Fertility : Journal of the British Fertility Society·D Nugent, A H Balen
Mar 12, 2013·Fertility and Sterility·UNKNOWN Ethics Committee of the American Society for Reproductive Medicine
Jan 1, 2013·Reproductive Biomedicine Online·E JauniauxR Maymon
Apr 5, 2011·Fertility and Sterility·Saralee GlasserLiat Lerner-Geva
Oct 14, 2009·Maturitas·Corina Schoen, Todd Rosen
Oct 23, 2016·Journal de gynécologie, obstétrique et biologie de la reproduction·A Vincent-RohfritschC Le Ray
Feb 21, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Andrea L TranquilliStefano Giannubilo
Apr 13, 2015·Journal of Reproductive Immunology·Lisa E E L O LashleyFrans H J Claas
Jun 23, 2005·American Journal of Obstetrics and Gynecology·Donna A Wiggins, Elliott Main
Jul 28, 2016·Fertility and Sterility·UNKNOWN Ethics Committee of the American Society for Reproductive Medicine. Electronic address: ASRM@asrm.org, UNKNOWN Ethics Committee of the American Society for Reproductive Medicine
Oct 30, 2016·Fertility and Sterility·Manon BosRosanne J Turner
May 21, 2015·Einstein·Evandro Eduardo CanhaçoReginaldo Guedes Coelho Lopes
Feb 24, 2001·Acta Obstetricia Et Gynecologica Scandinavica·V Söderström-AnttilaO Hovatta
Jun 5, 2003·Andrologia·T Strowitzki
Oct 3, 2019·Journal of Human Reproductive Sciences·Sesh Kamal SunkaraMohan S Kamath
Dec 29, 2020·Best Practice & Research. Clinical Obstetrics & Gynaecology·Elpiniki ChronopoulouSrividya Seshadri
Jan 12, 2021·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Yoko GekkaTakahiro Yamashita
Feb 3, 2011·Deutsches Ärzteblatt International·Ulrich PecksJoseph Neulen
Nov 28, 2008·Menopause International·Anna Smajdor
Oct 5, 2021·Archives of Gynecology and Obstetrics·J AltmannA Weichert
Jun 29, 2011·Transplant Immunology·Marie-Louise P van der HoornFrans H J Claas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.