Oocyte fertilization in vitro is associated with high follicular immunoreactive beta-endorphin levels.

Journal of Endocrinological Investigation
F FacchinettiA R Genazzani

Abstract

Follicular fluid (FF) levels of immuno reactive beta-Endorphin (i.r. beta-EP), i.r. gamma-Endorphin (i.r. gamma-EP), i.r. alpha-melanocyte-stimulating hormone (i.r. alpha-MSH), androgens and estrogens were measured in 76 preovulatory follicles obtained, after gonadotropin stimulation from 19 women undergoing in vitro fertilization (IVF). The aim of the study was to investigate the relationships existing between peptide contents of FF and both oocyte-cumulus-corona-complex (OCCC) maturity and the success of IVF. Peptides and steroids were measured by RIA after FF extraction with liquid chromatography and ethyl-ether, respectively. Out of the total of 76 oocytes, 52 were fertilized in vitro and 35 of them underwent normal cleavage and were transferred. Among the three peptides, only i.r. beta-EP levels were higher in FF from follicles which contained oocytes that were subsequently fertilized (127.6 +/- 16.2 pmol/L mean +/- SE) than in FF from follicles which contained oocytes that did not subsequently fertilized (62.9 +/- 8.4, p less than 0.04). Independent of subsequent fertilization, i.r. alpha-MSH values in FF were 5 times higher than those of i.r. beta-EP and i.r. gamma-EP. In the presence of a morphologically mature oocyte, ...Continue Reading

References

Jan 1, 1978·Clinical Endocrinology·A R GenazzaniR Corda
Nov 1, 1986·The Journal of Clinical Endocrinology and Metabolism·F FacchinettiA R Genazzani
Oct 1, 1986·Neuropeptides·T LaatikainenT Wahlström
May 1, 1987·American Journal of Obstetrics and Gynecology·F A AleemA L Southren
Jun 1, 1988·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C Vermeulen-MeinersJ H Thijssen
Jul 1, 1987·American Journal of Obstetrics and Gynecology·F PetragliaA R Genazzani
Feb 1, 1987·Journal of in Vitro Fertilization and Embryo Transfer : IVF·M A BergerJ G Schenker
Dec 28, 1983·Biochemical and Biophysical Research Communications· Bakalkin GYaM I Titov
Apr 1, 1984·Fertility and Sterility·E RudakB Goldman

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Citations

May 6, 2009·Reproductive Biology and Endocrinology : RB&E·Alberto RevelliPaolo Rinaudo
Jan 1, 2013·International Journal of Reproductive Medicine·C McRaeJ Fisher

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