Oocyte quality reflected by follicular fluid analysis in poly cystic ovary syndrome (PCOS): a hypothesis based on intermediates of energy metabolism

Medical Hypotheses
Bikas K AryaKoel Chaudhury

Abstract

There is no clear acceptance of specific follicular fluid biomarker and its correlation with oocyte quality or related embryo variable till now. Most of the studies analyze correlation between certain biomolecules and the oocyte quality using single variable, instead of multivariate analysis algorithms. Our hypothesis is not based on single biomarker discovery, but attempts to explain oocyte quality in terms of energy metabolic pathways by considering its various intermediates. Reduced availability of glucose in the oocytes and follicular cells caused by defective transportation of glucose is expected in polycystic ovary syndrome (PCOS). This initiates alternative pathways to utilize fatty acid, amino acids etc. for energy as a compensatory mechanism to deal with the energy requirement. These compensations can be reflected by altered levels of various biomolecules in follicular fluid (e.g. ketone bodies, lipids, amino acids, lactate, pyruvate etc.). The amount of compensation, in order to meet the energy requirement can be directly correlated to quality of oocytes and better outcome after in vitro fertilization (IVF) in PCOS cases. This can be predicted with fair accuracy by doing a multivariate analysis of altered levels of va...Continue Reading

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Citations

May 17, 2012·Journal of Ovarian Research·Rosalbino Isabella, Emanuela Raffone
Jun 4, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Arturo BevilacquaZdravko A Kamenov
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Nov 22, 2013·The Journal of Reproduction and Development·Ewelina WarzychDorota Lechniak
Nov 1, 2016·International Journal of Endocrinology·Deepika Garg, Reshef Tal
Aug 3, 2018·Journal of Assisted Reproduction and Genetics·Maria Antonietta Castiglione MorelliAngela Ostuni
Apr 29, 2020·Zygote : the Biology of Gametes and Early Embryos·M JamilR Cadi
Nov 23, 2019·International Journal of Molecular Sciences·Anna WojciechowskaJoanna Wojtkiewicz
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Jan 5, 2019·Current Medicinal Chemistry·Igor GovorovEduard Komlichenko
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Aug 20, 2018·The Journal of Steroid Biochemistry and Molecular Biology·Lingyan LiuHuai-L Feng
May 5, 2021·Seminars in Reproductive Medicine·Simon AlesiAya Mousa

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