Oocyte-triggering day progesterone levels and endometrial appearance in normoresponders undergoing IVF/ICSI cycles: a hypothesis and a study protocol

Hormone Molecular Biology and Clinical Investigation
Charalampos SiristatidisGeorge Daskalakis

Abstract

In this report, we propose a study protocol capable of improving IVF outcomes in subfertile women with expected normal ovarian response. This proposal derives from conflicting published data and observations in our daily practice, concerning the negative impact of progesterone (P4) elevation at the day of oocyte triggering on pregnancy outcomes. Our hypothesis points to the combination of two previous "suspects" of reduced success after assisted reproduction techniques (ART) - the endometrium ultrasonographic parameters and P4 elevation at the day of oocyte triggering on their impact on pregnancy outcomes. Up-to-the minute data show that, there is a different impact of elevated P4 in fresh, frozen and donor cycles, whereas there are plenty of reports pointing to a different endometrial gene expression on different P4 measurements. Gaps in the literature are linked with a variation of the measurements of P4, its cycle-to-cycle reproducibility, the different cut-off levels used, the impact of various protocols of ovarian stimulation and the limitations of systematic reviews originating from the initial studies. Our hypothesis states that the combination of P4 values and endometrial ultrasound parameters at the day of oocyte trigg...Continue Reading

References

Sep 20, 2006·Human Reproduction Update·Hanna Achache, Ariel Revel
May 22, 2009·Journal of Assisted Reproduction and Genetics·Hisham Ali SalehMohamed Draz
Jan 29, 2011·Reproductive Biomedicine Online·I Van VaerenberghC Bourgain
Mar 2, 2012·Reproductive Biomedicine Online·M Al-AzemiH M Fatemi
Jul 28, 2013·Human Reproduction·Jingjuan JiZijiang Chen
Jul 30, 2014·Reproductive Biology and Endocrinology : RB&E·Antonio RequenaJuan Antonio García-Velasco
Jan 7, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Shuo YangJie Qiao
Mar 27, 2015·Current Opinion in Obstetrics & Gynecology·Human M Fatemi, Inge Van Vaerenbergh
Jul 15, 2015·Clinical and Experimental Reproductive Medicine·Ju Hee ParkSeok Hyun Kim
Sep 30, 2016·Journal of Reproductive Immunology·Judith E CartwrightAlison E Wallace
Mar 21, 2017·Reproductive Biomedicine Online·Eva R GroenewoudUNKNOWN ANTARCTICA Study Group

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