OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation.

PloS One
Yan CuiQian Tao

Abstract

Identification of tumor suppressor genes (TSGs) silenced by CpG methylation uncovers the molecular mechanism of tumorigenesis and potential tumor biomarkers. Loss of heterozygosity at 11q25 is common in multiple tumors including nasopharyngeal carcinoma (NPC). OPCML, located at 11q25, is one of the downregulated genes we identified through digital expression subtraction. Semi-quantitative RT-PCR showed frequent OPCML silencing in NPC and other common tumors, with no homozygous deletion detected by multiplex differential DNA-PCR. Instead, promoter methylation of OPCML was frequently detected in multiple carcinoma cell lines (nasopharyngeal, esophageal, lung, gastric, colon, liver, breast, cervix, prostate), lymphoma cell lines (non-Hodgkin and Hodgkin lymphoma, nasal NK/T-cell lymphoma) and primary tumors, but not in any non-tumor cell line and seldom weakly methylated in normal epithelial tissues. Pharmacological and genetic demethylation restored OPCML expression, indicating a direct epigenetic silencing. We further found that OPCML is stress-responsive, but this response is epigenetically impaired when its promoter becomes methylated. Ecotopic expression of OPCML led to significant inhibition of both anchorage-dependent and -...Continue Reading

References

Jan 10, 1997·The Journal of Biological Chemistry·K LangnaeseE D Gundelfinger
Apr 5, 2002·Nature·Ina RheeBert Vogelstein
Jun 4, 2002·Nature Reviews. Genetics·Peter A Jones, Stephen B Baylin
Aug 22, 2002·Human Molecular Genetics·Qian TaoKeith D Robertson
Nov 27, 2002·Seminars in Cancer Biology·Nancy Raab-Traub
Dec 11, 2003·Molecular and Cellular Neurosciences·Kathie L EaglesonPat Levitt
Feb 19, 2004·Journal of the National Cancer Institute·Renske D M SteenbergenPeter J F Snijders
Sep 3, 2004·Nature Reviews. Cancer·Steven A Belinsky
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Joseph KwongDolly P Huang
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jianming YingQian Tao
Feb 24, 2006·Nature Reviews. Cancer·Stephen B Baylin, Joyce E Ohm
May 25, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Qian TaoPaul G Murray
Jan 24, 2007·Neuropathology and Applied Neurobiology·J E ReedC Walker
May 5, 2007·Expert Reviews in Molecular Medicine·Qian Tao, Anthony T C Chan
Jul 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hongchuan JinQian Tao
Apr 17, 2008·Cancer Research·Mohammad Obaidul HoqueDavid Sidransky
May 20, 2016·Cold Spring Harbor Perspectives in Biology·Stephen B Baylin, Peter A Jones

❮ Previous
Next ❯

Citations

May 19, 2010·Biomarkers in Medicine·Hirendra Nath Banerjee, Mukesh Verma
Jan 30, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Jean S FlemingGrant C Sellar
Oct 16, 2008·World Journal of Gastroenterology : WJG·Jin-Shui ZhuQiang Zhang
Mar 3, 2011·Carcinogenesis·Shirley OghamianPeter W Laird
Mar 29, 2011·Chinese Journal of Cancer·Li-Li LiQian Tao
Jan 1, 2010·Genetics and Molecular Biology·Patricia Oliveira CarminatiElza Tiemi Sakamoto-Hojo
Nov 9, 2011·Chinese Journal of Cancer·Xiao-Tong Hu, Chao He
Nov 9, 2011·Chinese Journal of Cancer·Ting-Xiu XiangQian Tao
Dec 18, 2013·Science Translational Medicine·Victor D FedorovMichel Sadelain
Jun 21, 2013·Expert Review of Molecular Diagnostics·Koji OtaniJun Yu
Feb 19, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Yu WuMin Fang
Dec 19, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Min-Ae SongPeter G Shields
Sep 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Abhik SahaErle S Robertson
Jan 29, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara Duarte-PereiraCarmen Jerónimo
Apr 6, 2016·Gastroenterology Research and Practice·Wael M Abdel-RahmanPäivi Peltomäki
Feb 9, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·D SchanzeG Stöber
Feb 24, 2011·Genes, Chromosomes & Cancer·Huei-Tzu ChienLing-Ling Hsieh
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Myriam LoyoDavid Sidransky
Mar 1, 2012·Cell Biochemistry and Function·Chiaki SugimotoSeiji Miyata
Jul 27, 2010·International Journal of Cancer. Journal International Du Cancer·Yiping HuangMyoung Sook Kim
Feb 6, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Rattaya AmornpisuttTemduang Limpaiboon
Sep 6, 2014·American Journal of Hypertension·Yun J SungDabeeru C Rao
May 15, 2012·Molecular & Cellular Proteomics : MCP·Joseph N BrownRichard D Smith
Mar 13, 2014·American Journal of Medical Genetics. Part a·Maoqing YePaul Grossfeld
Oct 17, 2018·Epigenomics·Sadegh FattahiHaleh Akhavan-Niaki
Mar 31, 2011·British Journal of Cancer·R SriraksaT Limpaiboon
Sep 15, 2018·Experimental and Therapeutic Medicine·Xinmin DongJiren Zhang
Feb 19, 2015·Current Opinion in Gastroenterology·Apinya JusakulBin Tean Teh

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis
environmental stress
environmental stresses

Software Mentioned

OPCML
CpG Island Searcher
Differential Gene Expression Displayer ( DGED )

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.