Open-access high-resolution mass spectrometry in early drug discovery

Journal of Mass Spectrometry : JMS
Steven R Thomas, Ute Gerhard

Abstract

Techniques such as mass spectrometry and NMR spectroscopy form an essential part of the medicinal chemist's toolbox for characterizing and assessing the purity of new molecules. Empowering medicinal chemists to gain early insight into their reaction products has a direct impact on productivity. Devolution of cutting-edge techniques from the specialist to the bench chemist also frees the specialist to concentrate on solving the more demanding of analytical problems. For open-access techniques to be taken up, they must be robust and be able to handle differing sample concentrations and varying sample complexities. This paper details the implementation of high-resolution liquid chromatography/mass spectrometry in open access to aid the medicinal chemist in characterizing desired products and identifying unexpected rearrangements, by-products and complete unknowns.

Citations

May 6, 2005·Journal of the American Society for Mass Spectrometry·David A Peake, Bradley L Ackermann
Jul 17, 2007·Journal of the American Society for Mass Spectrometry·Justin G StrohJames M Lau
Jul 19, 2008·Annual Review of Analytical Chemistry·Bradley L AckermannAjai K Chaudhary
May 10, 2005·Rapid Communications in Mass Spectrometry : RCM·Chris Petucci, Larry Mallis
Jul 19, 2016·Rapid Communications in Mass Spectrometry : RCM·Julie M Herniman, G John Langley
Oct 28, 2005·Journal of Medicinal Chemistry·Gabriele CrucianiRiccardo Vianello

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