PMID: 11930899Apr 5, 2002Paper

Open clinical trial of rifabutin and clarithromycin therapy in Crohn's disease

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
I ShafranJ Sandoval

Abstract

Crohn's disease, an inflammatory bowel disease in humans, has a suspected aetiology of Mycobacterium avium subsp. Paratuberculosis. To evaluate the role of rifabutin and clarithromycin anti-Mycobacterium avium subsp. Paratuberculosis treatment in Crohn's disease patients using an open clinical trial. . A total of 36 patients with acute presentations of Crohn's disease, whose sera tested positive against p35 and p36 antigens (two recombinant proteins of Mycobacterium avium subsp. Paratuberculosis), were selected for treatment with rifabutin and macrolide antibiotic therapy Rifabutin and macrolide antibiotic therapy medications included 250 mg 1 po bid clarithromycin and 150 mg 1 po bid Ri-fabutin accompanied with a probiotic. Crohn's disease patients' response to rifabutin and macrolide antibiotic therapy was monitored over a period ranging from 4 to 17 months. Seven patients (19.4%) withdrew from the study since they were unable to tolerate medications. Of the remaining 29 patients, 21 (58.3%) reached a sustained state of improvement, traditionally defined as a decrease of 70 points between their entrance and exit Crohn's disease activity index scores together with the absence of the need of all other Crohn's medications, such ...Continue Reading

References

Jan 1, 1990·Journal of Gastroenterology and Hepatology·P R Gibson
Aug 1, 1987·Journal of the Royal Society of Health·Z A Zein
Mar 1, 1997·The Journal of Antimicrobial Chemotherapy·G P GuiJ Hermon-Taylor
Aug 15, 1998·Baillière's Clinical Gastroenterology·G JärnerotC Tysk
Feb 13, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D SchwartzS A Naser

❮ Previous
Next ❯

Citations

Apr 3, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·J Hermon-Taylor
May 22, 2009·The Journal of Antimicrobial Chemotherapy·Manju Y KrishnanMichael T Collins
Mar 3, 2005·Journal of Gastroenterology and Hepatology·Toshifumi Ohkusa, Nobuhiro Sato
Jul 5, 2007·Journal of Gastroenterology and Hepatology·Satoko InoueTsutomu Chiba
Dec 12, 2007·Antimicrobial Agents and Chemotherapy·Sreedhar SubramanianBarry J Campbell
Jan 17, 2004·Clinical Microbiology Reviews·Todd P PrimmJoseph O Falkinham
Jul 6, 2007·Journal of Medical Case Reports·David HaiderNigel Davies
May 22, 2010·Case Reports in Medicine·Semiu Eniola FolaranmiGreg Holdstock
Dec 19, 2013·TheScientificWorldJournal·Lingna YeJianfeng Cheng
Dec 11, 2002·Journal of Internal Medicine·S Ardizzone, G Bianchi Porro
Oct 17, 2015·Expert Review of Gastroenterology & Hepatology·Adrienne L McNeesDavid Y Graham
Jan 7, 2015·Pharmacology & Therapeutics·Giovanni CammarotaDiego Currò
May 22, 2009·Gastroenterología y hepatología·José Ignacio Fortea OrmaecheaIgnacio Marín-Jiménez
Jun 16, 2007·Gastroenterology·Laurent Peyrin-BirouletJean-Frédéric Colombel
Mar 21, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·T J BorodyS Tye
Mar 5, 2008·Alimentary Pharmacology & Therapeutics·K LeiperJ M Rhodes
Jan 17, 2012·Critical Reviews in Microbiology·Rodrick J ChiodiniRichard W McCallum
Aug 9, 2005·Current Medical Research and Opinion·Ira Shafran, Lorin K Johnson
Jun 19, 2015·Clinical and Translational Gastroenterology·Parth J ParekhDavid A Johnson
Mar 11, 2015·Current Infectious Disease Reports·Horacio Bach
Oct 19, 2004·Annual Review of Microbiology·Ofelia ChaconRaúl G Barletta
Jul 17, 2012·Digestive Diseases·Guillaume P Pineton de ChambrunJean-Frédéric Colombel
Oct 22, 2011·Expert Review of Clinical Immunology·William ChamberlinJordana Campbell
Dec 25, 2008·Critical Reviews in Clinical Laboratory Sciences·Sandra MacfarlaneGeorge T Macfarlane
Mar 11, 2005·Expert Review of Anti-infective Therapy·Marie-Thérèse Labro
Jan 18, 2005·The Journal of International Medical Research·M E OnwuamaegbuC Soare
Jul 11, 2006·Medical Hypotheses·C Thomas Dow
Jul 5, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·R Balfour Sartor
Dec 2, 2004·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·P ChandranO Eremin
Apr 1, 2004·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Sung Jae ShinAlfonso Torres
Feb 16, 2008·Inflammatory Bowel Diseases·Harry SokolGerald W Tannock
Jan 25, 2007·Inflammatory Bowel Diseases·Hiroshi TamagawaHiroshi Kiyono
Jun 29, 2006·Inflammatory Bowel Diseases·Molly Perencevich, Robert Burakoff
May 30, 2008·Inflammatory Bowel Diseases·Ira Shafran, Patricia Burgunder
Mar 6, 2007·The American Journal of Gastroenterology·William ChamberlinSaleh A Naser
Jul 27, 2007·Journal of Leukocyte Biology·Gerben FerwerdaMihai G Netea
Oct 27, 2006·Current Opinion in Ophthalmology·Simon R J TaylorSusan Lightman
Sep 19, 2015·The European Respiratory Journal·Nicholas WintersDick Menzies
Apr 23, 2019·Plant Disease·Gustavo A Díaz-CruzBryan J Cassone

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
D SchwartzS A Naser
Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
T J BorodyS Tye
Proceedings of the National Academy of Sciences of the United States of America
D MishinaRobert J Greenstein
© 2022 Meta ULC. All rights reserved