PMID: 701375Oct 1, 1978Paper

Open junctions in the endothelium of the postcapillary venules of the diaphragm

The Journal of Cell Biology
N SimionescuG E Palade

Abstract

We have previously established that approximately 30% of the endothelial junctions in the pericytic venules of the mouse diaphragm are open to a gap of approximately 30--60 A, and are fully permeated by hemeundecapeptide (H11P) (mol diam approximately 20 A). To estimate the size limit for molecules that can permeate these junctions, we have administered graded tracers intravenously and studied their behavior at the level of pericytic venules in bipolar microvascular fields (BMFs) in the mouse diaphragm. Horseradish peroxidase (HRP) (mol diam approximately 50 A) permeated only approximately 50% of the open junctions of the venular endothelium. Outflow through venular junctions appeared to be modest since the tracer remained restricted to the perivenular spaces. Hemoglobin (Hb, mol diam 64 x 55 x 50 A) permeated only a few (less than 5%), and ferritin (mol diam 110 A), practically none, of the endothelial junctions of the pericytic venules. The findings suggest that under normal conditions the size limit for permeant molecules for open venular junctions is approximately 60 A. Replicas of freeze-fracture preparations from appropriate regions in BMF showed that the intercellular junctions of the venular endothelium have the same or...Continue Reading

References

Dec 1, 1977·Circulation Research·E M Renkin
Dec 1, 1975·The Journal of Cell Biology·M SimionescuG E Palade
Sep 1, 1969·The Journal of Cell Biology·G MajnoM Leventhal
Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky
Feb 1, 1978·The Journal of Cell Biology·S L Wissig, M C Williams
Dec 1, 1961·The Journal of Biophysical and Biochemical Cytology·G MAJNOG I SCHOEFL
Dec 1, 1961·The Journal of Biophysical and Biochemical Cytology·G MAJNO, G E PALADE

❮ Previous
Next ❯

Citations

Jan 1, 1983·Anatomy and Embryology·H Bartels, T Wang
Jan 10, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Anjali PandeyKrishan Avtar Suri
Apr 2, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Masahiro Murakami, Michael Simons
Aug 9, 2008·Cell and Tissue Research·Philippe G FrankMichael P Lisanti
Jun 8, 2001·The American Journal of Pathology·T EzakiD M McDonald
Nov 15, 2011·Molecular Pharmaceutics·Yashveer SinghPatrick J Sinko
Jan 1, 1990·Eye·A R Nagy, T E Ogden
Dec 24, 1997·British Journal of Pharmacology·M Taherzadeh, J B Warren
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J A HolashP A Stewart
May 1, 1992·The Journal of Dermatologic Surgery and Oncology·M P Goldman
Jan 1, 1985·Acta Physiologica Scandinavica·S P Olesen
Jun 23, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Pascal StuelsatzZipora Yablonka-Reuveni
Jul 25, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·A TafazzoliM P Goldman
Oct 4, 2014·Journal of Cardiovascular Translational Research·Devendra A SawantEd W Childs
Jan 1, 1982·Virchows Archiv. A, Pathological Anatomy and Histology·T ZandI Joris
Jan 1, 1982·Virchows Archiv. A, Pathological Anatomy and Histology·N HinglaisJ Bariety
Jan 1, 1980·Anatomy and Embryology·F B WoodingR B Heap
Jan 1, 1996·Springer Seminars in Immunopathology·K Selmaj
Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·N O Nilsen
Dec 18, 2007·Endothelium : Journal of Endothelial Cell Research·Beatrice NicoDomenico Ribatti
Sep 17, 2013·Journal of Pharmaceutical Sciences·Ajit S NarangMunir A Hussain
May 1, 1990·The Anatomical Record·L H HoffmanP C Hoos
Apr 26, 2011·Advanced Drug Delivery Reviews·Ajit S Narang, Sailesh Varia
Apr 1, 2008·Annals of the New York Academy of Sciences·Emily VandenbrouckeAsrar B Malik
Jun 1, 1995·Metabolism: Clinical and Experimental·T YamashitaH Nawata
Oct 30, 1998·The Journal of Laboratory and Clinical Medicine·K NakaiT A Takahashi
Sep 1, 1981·Microvascular Research·L D Plonsky, J Boyles
Oct 1, 1992·Experimental and Molecular Pathology·K SawadaS Suehiro
Jan 1, 1982·Annals of the New York Academy of Sciences·M SimionescuG E Palade
Jan 1, 1982·Annals of the New York Academy of Sciences·N SimionescuM Simionescu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.