Open nanofluidic films with rapid transport and no analyte exchange for ultra-low sample volumes

Lab on a Chip
N B TwineJ Heikenfeld

Abstract

Moving to ultra-low (<100 nL) sample volumes presents numerous challenges, many of which can be resolved by implementation of open nanofluidic films. These nanofluidic films are fabricated using a hexagonal network of gold-coated open microchannels which capture all of the following innovative advantages: (1) sample volumes of <100 nL cm-2; (2) zero analyte exchange and loss with the film materials; (3) rapid and omni-directional wicking transport of >500 nL min-1 per square of film; (4) ultra-simple roll-to-roll fabrication; (5) stable and bio-compatible super-hydrophilicity for weeks in air by peptide surface modification. Validation includes both detailed in vitro characterization and in vivo validation with sweat transport from the human skin. Sampling times (skin-to-sensor) of <3 min were achieved, setting new benchmarks for the field of wearable sweat sensing. This work addresses significant challenges for sweat biosensing, or for any other nano-liter regime (<100 nL) fluid sampling and sensing application.

References

Jan 5, 2007·Lab on a Chip·Michael W Toepke, David J Beebe
Nov 26, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Jaroslaw Drelich, Emil Chibowski
Apr 10, 2012·Annals of Biomedical Engineering·Jack D WangMohamed ElSayed
Apr 12, 2013·Lab on a Chip·Linlin HouJason Heikenfeld
Jul 8, 2014·Nature Communications·Yurui XueWenke Zhang
Jan 11, 2017·Proceedings of the National Academy of Sciences of the United States of America·Netzahualcóyotl Arroyo-CurrásKevin W Plaxco
Nov 29, 2017·Lab on a Chip·J HeikenfeldJ Kim

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Citations

Feb 26, 2019·Nature Biotechnology·Jason HeikenfeldBenjamin A Katchman
Feb 6, 2021·Sensors and Actuators. B, Chemical·Roozbeh GhaffariTyler R Ray
Mar 7, 2021·Membranes·Genís Rabost-GarciaJasmina Casals-Terré
Mar 25, 2021·Nature Communications·Hnin Yin Yin NyeinAli Javey
Nov 1, 2020·Biosensors & Bioelectronics·Jihong MinWei Gao
Jun 10, 2021·Lab on a Chip·Yen-Chi ChenYing-Chih Liao
Jan 29, 2019·Accounts of Chemical Research·Michael C BrothersSteve S Kim
Dec 10, 2021·Lab on a Chip·Aditi R NaikJames J Watkins

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Methods Mentioned

BETA
biosensing

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