Open questions: CRISPR biology

BMC Biology
Eugene V Koonin

Abstract

CRISPR-Cas systems, the purveyors of adaptive immunity in archaea and bacteria and sources of the new generation of genome engineering tools, have been studied in exquisite molecular detail. However, when it comes to biological functions, ecology, and evolution of CRISPR-Cas, many more intriguing questions remain than there are answers.

References

Nov 10, 2010·MBio·Kelli L Palmer, Michael S Gilmore
Mar 7, 2014·Microbiology and Molecular Biology Reviews : MMBR·Rogier LouwenJohn van der Oost
Apr 8, 2014·Nature Reviews. Microbiology·Edze R WestraPeter C Fineran
Sep 29, 2015·Nature Reviews. Microbiology·Kira S MakarovaEugene V Koonin
Aug 6, 2016·Science·Prarthana MohanrajuJohn van der Oost
Nov 30, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Eugene V Koonin, Feng Zhang
Aug 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Joseph E PetersEugene V Koonin
Oct 7, 2017·Genome Biology and Evolution·Eugene V Koonin, Kira S Makarova

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Citations

Oct 21, 2020·Journal of Bioinformatics and Computational Biology·Tatiana Lenskaia, Daniel Boley

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Related Concepts

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Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). CRISPR-Cas system enables the editing of genes to create or correct mutations. Discover the latest research on CRISPR here.

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