Open questions for harnessing autophagy-modulating drugs in the SARS-CoV-2 war: hope or hype?

Autophagy
Patrick BrestBaharia Mograbi

Abstract

At a time when the world faces an emotional breakdown, crushing our dreams, if not, taking our lives, we realize that together we must fight the war against the COVID-19 outbreak even if almost the majority of the scientific community finds itself confined at home. Every day, we, scientists, listen to the latest news with its promises and announcements. Across the world, a surge of clinical trials trying to cure or slow down the coronavirus pandemic has been launched to bring hope instead of fear and despair. One first proposed clinical trial has drawn worldwide hype to the benefit of chloroquine (CQ), in the treatment of patients infected by the recently emerged deadly coronavirus (SARS-CoV-2). We should consider this information in light of the long-standing anti-inflammatory and anti-viral properties of CQ-related drugs. Yet, none of the articles promoting the use of CQ in the current pandemic evoked a possible molecular or cellular mechanism of action that could account for any efficacy. Here, given the interaction of viruses with macroautophagy (hereafter referred to as autophagy), a CQ-sensitive anti-viral safeguard pathway, we would like to discuss the pros, but also the cons concerning the current therapeutic options ta...Continue Reading

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Citations

Dec 1, 2020·Autophagy·Marie-Angela DomdomBaharia Mograbi
Nov 7, 2020·Autophagy·Elizabeth Delorme-Axford, Daniel J Klionsky
May 1, 2021·International Journal of Molecular Sciences·Gustavo José da Silva PereiraClaudia Bincoletto
Aug 14, 2021·Frontiers in Cell and Developmental Biology·Yafei QuQiming Liang
Aug 28, 2021·Cells·Ankit Shroff, Taras Y Nazarko

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Methods Mentioned

BETA
glycosylation

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