Open resource of clinical data from patients with pneumonia for the prediction of COVID-19 outcomes via deep learning.

Nature Biomedical Engineering
Wanshan NingZheng Wang

Abstract

Data from patients with coronavirus disease 2019 (COVID-19) are essential for guiding clinical decision making, for furthering the understanding of this viral disease, and for diagnostic modelling. Here, we describe an open resource containing data from 1,521 patients with pneumonia (including COVID-19 pneumonia) consisting of chest computed tomography (CT) images, 130 clinical features (from a range of biochemical and cellular analyses of blood and urine samples) and laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clinical status. We show the utility of the database for prediction of COVID-19 morbidity and mortality outcomes using a deep learning algorithm trained with data from 1,170 patients and 19,685 manually labelled CT slices. In an independent validation cohort of 351 patients, the algorithm discriminated between negative, mild and severe cases with areas under the receiver operating characteristic curve of 0.944, 0.860 and 0.884, respectively. The open database may have further uses in the diagnosis and management of patients with COVID-19.

References

Jul 16, 2014·PeerJ·Stéfan van der WaltUNKNOWN scikit-image contributors
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Feb 23, 2020·Radiology·Zi Yue ZuLong Jiang Zhang
Feb 28, 2020·The Lancet Infectious Diseases·Heshui ShiChuansheng Zheng
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 4, 2020·Nature Microbiology·UNKNOWN Coronaviridae Study Group of the International Committee on Taxonomy of Viruses
Mar 12, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rui LiuChengliang Zhu
Mar 18, 2020·Lancet·Andrea Remuzzi, Giuseppe Remuzzi
Mar 18, 2020·Travel Medicine and Infectious Disease·Alfonso J Rodriguez-MoralesUNKNOWN Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19). Electronic address: https://www.lancovid
Jun 27, 2020·Physical and Engineering Sciences in Medicine·Dipayan DasUmapada Pal
Apr 24, 2020·MedRxiv : the Preprint Server for Health Sciences·S. WangBo Xu

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Citations

Feb 10, 2021·Radiology·Jeffrey P KanneNicola Sverzellati
May 1, 2021·Medicina·Franca DipaolaRaffaello Furlan
Jun 5, 2021·NPJ Digital Medicine·Amara TariqImon Banerjee
Jun 22, 2021·Journal of the American Medical Informatics Association : JAMIA·Yi GuoJiang Bian
Jul 1, 2021·Computational and Structural Biotechnology Journal·Kai ZhouTiannan Guo
Jul 14, 2021·Scientific Reports·Wentao ZhaoXinguo Qiu
Sep 3, 2021·Computational and Structural Biotechnology Journal·Peiran JiangYaping Guo

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Methods Mentioned

BETA
PCR
ESR
X-ray
flow cytometry
feature extraction

Software Mentioned

Scikit
STA
HUST
ChexNet
learn
iCTCF
Inception
2000
OpenCV
TensorFlow

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