Open-Source Wax RepRap 3-D Printer for Rapid Prototyping Paper-Based Microfluidics

Journal of Laboratory Automation
Joshua M PearceC L Heldt

Abstract

The open-source release of self-replicating rapid prototypers (RepRaps) has created a rich opportunity for low-cost distributed digital fabrication of complex 3-D objects such as scientific equipment. For example, 3-D printable reactionware devices offer the opportunity to combine open hardware microfluidic handling with lab-on-a-chip reactionware to radically reduce costs and increase the number and complexity of microfluidic applications. To further drive down the cost while improving the performance of lab-on-a-chip paper-based microfluidic prototyping, this study reports on the development of a RepRap upgrade capable of converting a Prusa Mendel RepRap into a wax 3-D printer for paper-based microfluidic applications. An open-source hardware approach is used to demonstrate a 3-D printable upgrade for the 3-D printer, which combines a heated syringe pump with the RepRap/Arduino 3-D control. The bill of materials, designs, basic assembly, and use instructions are provided, along with a completely free and open-source software tool chain. The open-source hardware device described here accelerates the potential of the nascent field of electrochemical detection combined with paper-based microfluidics by dropping the marginal cost...Continue Reading

References

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Citations

Jul 17, 2016·Journal of Laboratory Automation·James M Gill, Alden S Hart
Mar 4, 2017·SLAS Technology·Edward Kai-Hua Chow
May 30, 2017·Nature Biotechnology·Kent S BolesDaniel G Gibson
Nov 7, 2017·Sensors·Rocio B DominguezAlfredo Márquez-Lucero
Apr 6, 2017·Analytical Chemistry·Michael D M DrydenAaron R Wheeler
Dec 13, 2016·Analytical Chemistry·Yuanyuan YangCharles S Henry

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Methods Mentioned

BETA
pregnancy test

Software Mentioned

OpenSCAD
Cura
RepRap
RepRaps
Cura LulzBot
Franklin
Repetier
Printrun
code

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