Operant behavior to obtain palatable food modifies ERK activity in the brain reward circuit

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Thomas GueganMiquel Martin

Abstract

Food palatability produces behavioral modifications that resemble those induced by drugs of abuse. Palatability-induced behavioral changes require both, the activation of the endogenous cannabinoid system, and changes in structural plasticity in neurons of the brain reward pathway. The ERK intracellular pathway is activated by CB1 receptors (CB1-R) and plays a crucial role in neuroplasticity. We investigated the activation of the ERK signaling cascade in the mesocorticolimbic system induced by operant training to obtain highly palatable isocaloric food and the involvement of the CB1-R in these responses. Using immunofluorescence techniques, we analyzed changes in ERK intracellular pathway activation in the mesocorticolimbic system of wild-type and CB1 knockout mice (CB1-/-) trained on an operant paradigm to obtain standard, highly caloric or highly palatable isocaloric food. Operant training for highly palatable isocaloric food, but not for standard or highly caloric food, produced a robust activation of the ERK signaling cascade in the same brain areas where this training modified structural plasticity. These changes induced by the operant training were absent in CB1-/-. We can conclude that the activation of the ERK pathway i...Continue Reading

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Citations

Sep 26, 2012·Nature Neuroscience·Ralph J DiLeoneMarina R Picciotto
Jun 27, 2013·The Journal of Pharmacology and Experimental Therapeutics·Lisa K BrentsWilliam E Fantegrossi
Jan 7, 2016·Frontiers in Molecular Neuroscience·Anne BieverEmma Puighermanal
Nov 17, 2017·Nature Reviews. Neuroscience·Nora D VolkowRuben Baler
Jan 10, 2018·Frontiers in Molecular Neuroscience·Emma PuighermanalEmmanuel Valjent
Jan 19, 2018·Scientific Reports·Sarah LalisseLauriane Ulmann

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