Operant conditioning of primate prefrontal neurons.

Journal of Neurophysiology
Shunsuke KobayashiMasamichi Sakagami

Abstract

An operant is a behavioral act that has an impact on the environment to produce an outcome, constituting an important component of voluntary behavior. Because the environment can be volatile, the same action may cause different consequences. Thus to obtain an optimal outcome, it is crucial to detect action-outcome relationships and adapt the behavior accordingly. Although prefrontal neurons are known to change activity depending on expected reward, it remains unknown whether prefrontal activity contributes to obtaining reward. We investigated this issue by setting variable relationships between levels of single-neuron activity and rewarding outcomes. Lateral prefrontal neurons changed their spiking activity according to the specific requirements for gaining reward, without the animals making a motor response. Thus spiking activity constituted an operant response. Data from a control task suggested that these changes were unlikely to reflect simple reward predictions. These data demonstrate a remarkable capacity of prefrontal neurons to adapt to specific operant requirements at the single-neuron level.

References

May 1, 1974·Journal of the Experimental Analysis of Behavior·J GibbonR L Thompson
Feb 28, 1969·Science·E E Fetz
Jul 1, 1995·Journal of Pediatric Surgery·M S LevyJ M Wilson
Mar 1, 1995·Neuropsychologia·P VendrellJ Grafman
Jul 19, 2000·Journal of Neurophysiology·W F AsaadE K Miller
Aug 10, 2000·Experimental Brain Research·J M Fuster
Apr 3, 2001·Annual Review of Neuroscience·E K Miller, J D Cohen
Mar 6, 2002·Journal of Neurophysiology·Shunsuke KobayashiOkihide Hikosaka
Jun 8, 2002·Science·Dawn M TaylorAndrew B Schwartz
Apr 5, 2003·Vision Research·Ralf Engbert, Reinhold Kliegl
Jul 12, 2003·Science·Kenji MatsumotoKeiji Tanaka
Jun 1, 1962·Journal of Comparative and Physiological Psychology·D P HENDRY
Oct 1, 1963·IEEE Transactions on Bio-medical Engineering·D A ROBINSON
Jan 27, 2004·Neuron·Elizabeth M TricomiJulie A Fiez
Jul 13, 2004·Science·S MusallamR A Andersen
Nov 29, 2005·Science·Kazuyuki SamejimaMinoru Kimura
Nov 1, 1980·Journal of the Experimental Analysis of Behavior·L J Hammond
May 1, 1985·Journal of the Experimental Analysis of Behavior·P R Killeen
Jan 1, 1988·Journal of the Experimental Analysis of Behavior·P Reed, J E Wright
Jan 1, 1991·Journal of the Experimental Analysis of Behavior·P Reed
Jul 14, 2006·Journal of Neurophysiology·Jonathan S CarpJonathan R Wolpaw
Mar 14, 2007·Current Opinion in Neurobiology·Masamichi Sakagami, Xiaochuan Pan
Oct 12, 2007·Journal of Neurophysiology·Takuro Ikeda, Okihide Hikosaka
Jan 16, 2008·Physiological Reviews·Jun Tanji, Eiji Hoshi
May 10, 2008·Neuron·Brian Lau, Paul W Glimcher
Jun 27, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Saori C TanakaJohn P O'Doherty
Oct 7, 2008·Trends in Neurosciences·Steven P Wise
Oct 17, 2008·Nature·Chet T MoritzEberhard E Fetz
Nov 26, 2008·Experimental Brain Research·Andrew F RossiLeslie G Ungerleider

❮ Previous
Next ❯

Citations

May 28, 2011·Science·Robert J Schafer, Tirin Moore
Jan 23, 2016·Current Opinion in Neurobiology·Matthew D GolubByron M Yu
Mar 13, 2014·Journal of Neural Engineering·Alik S Widge, Chet T Moritz
Aug 19, 2018·Language, Speech, and Hearing Services in Schools·Joanne A DeocampoChristopher M Conway

❮ Previous
Next ❯

Software Mentioned

Matlab

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Nicolas FrémauxWulfram Gerstner
Biological cybernetics
Wulfram Gerstner, Werner M Kistler
Proceedings of the National Academy of Sciences of the United States of America
Ji-Chuan ZhangGuo-Qiang Bi
© 2021 Meta ULC. All rights reserved