PMID: 7225872May 18, 1981Paper

Operant control of epileptic neurons in chronic foci of monkeys

Brain Research
A R Wyler, K J Burchiel

Abstract

(1) Six Macaca mulatta monkeys were rendered chronically epileptic by subpial alumina injection in left precentral cortex. The monkeys were then trained to operantly control the firing patterns of single units from the epileptic focus and contralateral homotopic cortex using a standardized paradigm. In 30 experiments, units were recorded simultaneously from both hemispheres. (2) For epileptic and normal neurons, there are no consistent relationships between cortical EEG spikes and unit firing. (3) Previous parameters for quantifying single unit epileptogenicity are not adequate for defining the complex spectrum and relative degree of unit abnormalities within the chronic focus. A primary difference between normal and epileptic neurons is that monkeys can modify the firing pattern and rate of the former but can modify, only slightly, the integrated firing rate of the latter. (4) A previously described 'non-burst' epileptiform firing pattern consisting of 8--18 msec doublets is investigated in further detail. This pattern may represent units along a continuum between normalcy and long-first-interval burst firing. (5) The majority of epileptic units' firing patterns become more normal when the monkey is reinforced to control the f...Continue Reading

References

Nov 24, 1978·Brain Research·A R Wyler, K J Burchiel
Nov 1, 1970·Electroencephalography and Clinical Neurophysiology·D A Prince, K J Futamachi
May 1, 1967·Electroencephalography and Clinical Neurophysiology·J S Lockard, R I Barensten
Sep 1, 1973·Experimental Neurology·A R WylerA A Ward
Mar 1, 1974·Experimental Neurology·A R Wyler
Aug 18, 1980·Brain Research·A R WylerC A Robbins
Dec 1, 1964·Journal of Neurosurgery·L E WESTRUMA A Ward

Citations

Jun 1, 1982·Experimental Neurology·A R Wyler
Mar 20, 2016·Epilepsy & Behavior : E&B·Ariel Tankus

Related Concepts

Alhydrogel
Insula of Reil
Operant Conditioning
Hemispheric Specialization
Electroencephalogram
Potentials, Event-Related
Macaca mulatta
Neurons
Corticobulbar Tracts
Non-epileptic Convulsion

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