PMID: 102407Nov 24, 1978Paper

Operant control of pyramidal tract neurons: the role of spinal dorsal columns

Brain Research
A R Wyler, K J Burchiel


A monkey was trained to control the firing patterns of precentral pyramidal tract neurons. The operant task was for the monkey to produce consecutive interspike intervals (ISI) within a requisite range, or target. The mean time off-target (error) is used to quantify the accuracy of control the monkey could assert over each PTN. Following partial destruction of the dorsal funiculi the number of PTNs driven by peripheral stimuli greatly decreased. Those PTNs which remained responsive to peripheral stimuli were as accurately controlled as those tested before column section, whereas, those PTNs unresponsive to peripheral stimuli were significantly less accurately controlled. The conclusion is that the monkey relies heavily upon proprioceptive feedback to operantly control precentral PTNs.


Oct 29, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R N Lemon, R Porter
Oct 29, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R N LemonR Porter
Oct 1, 1971·Experimental Neurology·R Melzack, J A Bridges


Sep 14, 1979·Brain Research·A R Wyler, C A Robbins
May 18, 1981·Brain Research·A R Wyler, K J Burchiel
May 23, 2006·Neurosurgical Focus·Roy A E Bakay
Oct 1, 1980·Experimental Neurology·A R Wyler, C A Robbins
Sep 1, 2015·Experimental Brain Research·E J Tehovnik, Lewis L Chen
Aug 18, 1980·Brain Research·A R WylerC A Robbins
Oct 15, 2013·Neuroscience·E J TehovnikW M Slocum
May 7, 2015·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·V A ShurkhayS A Goryainov

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