Operated hepatocellular carcinoma in two HIV- and HCV-positive hemophilic patients

Journal of Hepato-biliary-pancreatic Surgery
Yoichi NarushimaHidemi Yamauchi

Abstract

Some hemophilic patients in Japan suffer from infections with both human immunodeficiency virus (HIV) and hepatitis virus because they received contaminated nonheated blood products. Coinfection with HIV appears to accelerate the course of chronic hepatitis. Although powerful antiviral therapy was introduced as HIV treatment and the prognosis of HIV patients was dramatically improved, the risk of rapid progression of hepatitis and carcinogenesis remains for the patients. Recently, we performed surgery for hepatocellular carcinoma (HCC) in two hemophilic patients with HIV and hepatitis C virus (HCV) coinfection. Case 1 was a 52-years-old man who suffered from liver cirrhosis, hypersplenism, and hyperammonemia due to portosystemic shunt. A recent abdominal computed tomography (CT) scan had revealed a low-density area in segment VI of the liver. Splenectomy and partial resection of the liver were performed. Case 2 was a 66-year-old man who had been diagnosed with chronic hepatitis at age 50, and HIV infection at age 52 years. When his serum alpha-fetoprotein level was increased, CT scan of the liver revealed a mass in segment VIII. Subsegmentectmy of the liver was performed. Although the CD4 value in each patient was lower than 20...Continue Reading

Citations

Sep 16, 2008·General Thoracic and Cardiovascular Surgery·Asako NamaiMasatoshi Akiyama
Jun 10, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·K Meijer, E B Haagsma
Aug 2, 2014·Journal of Hepato-biliary-pancreatic Sciences·Yoshikuni InokawaYasuhiro Kodera
Nov 18, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Nicolas GolseEric Vibert

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