Operating a treatment planning system using a deep-reinforcement learning-based virtual treatment planner for prostate cancer intensity-modulated radiation therapy treatment planning.

Medical Physics
Chenyang ShenXun Jia

Abstract

In the treatment planning process of intensity-modulated radiation therapy (IMRT), a human planner operates the treatment planning system (TPS) to adjust treatment planning parameters, for example, dose volume histogram (DVH) constraints' locations and weights, to achieve a satisfactory plan for each patient. This process is usually time-consuming, and the plan quality depends on planer's experience and available planning time. In this study, we proposed to model the behaviors of human planners in treatment planning by a deep reinforcement learning (DRL)-based virtual treatment planner network (VTPN), such that it can operate the TPS in a human-like manner for treatment planning. Using prostate cancer IMRT as an example, we established the VTPN using a deep neural network developed. We considered an in-house optimization engine with a weighted quadratic objective function. Virtual treatment planner network was designed to observe an intermediate plan DVHs and decide the action to improve the plan by changing weights and threshold dose in the objective function. We trained the VTPN in an end-to-end DRL process in 10 patient cases. A plan score was used to measure plan quality. We demonstrated the feasibility and effectiveness of...Continue Reading

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Citations

Oct 19, 2020·Medical Physics·William Thomas Hrinivich, Junghoon Lee
Oct 30, 2020·International Journal of Radiation Oncology, Biology, Physics·Jiahan ZhangQ Jackie Wu
May 13, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Ana Barragán-MonteroJohn A Lee
May 23, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Davide CusumanoLuca Indovina
Jul 27, 2021·Physics and Imaging in Radiation Oncology·Matthew FieldLois Holloway
Jul 8, 2021·Journal of Applied Clinical Medical Physics·Shadab MominXiaofeng Yang
Sep 15, 2021·Medical Physics·Charles HuangLei Xing
Aug 6, 2021·Physics in Medicine and Biology·Noah BiceNeil Kirby

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