PMID: 8938651Nov 1, 1996Paper

Operational characteristics of the 5-HT1-like receptors mediating external carotid vasoconstriction in vagosympathectomized dogs. Close resemblance to the 5-HT1D receptor subtype

Naunyn-Schmiedeberg's Archives of Pharmacology
Carlos M VillalónDavid Centurión

Abstract

It has recently been shown that the external carotid vasoconstrictor response to 5-HT in the dog is primarily mediated by sumatriptan-sensitive 5-HT1-like receptors; however, the fact that these receptors are not blocked by metergoline, a 5-HT1D ligand, raises questions about their possible correlation with the 5-HT1D receptor subtype. Since a number of drugs display high affinity for the 5-HT1D (GR127935) and 5-HT1F (e.g. methysergide and oxymetazoline) receptor subtypes, in this study we have used these drugs to determine whether the above vasoconstrictor 5-HT1-like receptors correlate with the 5-HT1D and/or 5-HT1F receptor subtypes. One-minute intracarotid infusions of 5-HT (0.3-30 micrograms/min), sumatriptan (1-30 micrograms/min), oxymetazoline (0.03-3 micrograms/min) and noradrenaline (0.3-3 micrograms/min) resulted in dose-dependent decreases in external carotid blood flow without changes in arterial blood pressure or heart rate. These vasoconstrictor responses remained unaltered after i.v. administration of physiological saline (0.015, 0.05 and 0.15 ml/kg; n = 4) or ritanserin (1 mg/kg; n = 5). In contrast, GR127935 (1, 3 and 10 micrograms/kg, n = 6) potently blocked the responses to 5-HT (unmasking a dose-dependent vas...Continue Reading

Citations

Oct 7, 1998·European Journal of Pharmacology·C M VillalónJ A Terrón
Jul 1, 1997·British Journal of Pharmacology·C M VillalónP R Saxena
Aug 19, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Carlos M Villalón, David Centurión
Jul 3, 2013·Expert Opinion on Pharmacotherapy·Martha B Ramírez RosasAntoinette Maassen Vandenbrink
Sep 24, 1998·Trends in Pharmacological Sciences·P R SaxenaC M Villalón
Mar 21, 2006·European Journal of Pharmacology·David CenturiónCarlos M Villalón
May 12, 2006·Cephalalgia : an International Journal of Headache·U ArulmaniP R Saxena

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