PMID: 20098020Jan 26, 2010Paper

Operative management of skull base malignant tumors arising from the nasal cavity and paranasal sinus: recent strategies used in 25 cases

Neurologia Medico-chirurgica
Hiroyuki JimboChihiro Fushimi

Abstract

Cancers of the paranasal sinuses and nasal cavity are the most common malignant tumors of the anterior and anterolateral skull base. The treatment of these tumors affecting the skull base is complex due to the significant anatomical features. We examined 25 patients, 17 males and 8 females with mean age 61 +/- 2 years. En bloc resections using anterior skull base resection, orbital resection, middle fossa resection, and combined procedures of these three resections were performed. Using a combination of adjuvant radiation and chemotherapy, we have achieved a 2-year disease-free survival rate of 90% in these cases. However, potential complications include cerebrospinal fluid leakage, meningitis, abscess formation, pneumocephalus, frontal brain contusion, trismus, and dysphagia as a functional complication. We believe that the optimal management of such malignant tumors involves a multimodal and multidisciplinary team approach. Here we present our recent institutional experience and treatment policy employed during the past 3 years.

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Citations

Mar 20, 2014·Semergen·M Ruiz-FelipeD Sáenz-Abad
Oct 1, 2015·International Journal of Oral and Maxillofacial Surgery·G MacíaJ Acero
Apr 17, 2012·Clinical Neurology and Neurosurgery·Rakesh RedhuSwetha H
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Dec 4, 2015·Current Problems in Diagnostic Radiology·Ashish ChawlaRaymond Chung
Aug 23, 2011·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Kyubo KimJoo-Heon Yoon
Feb 7, 2018·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Yi-Chan LeeKai-Ping Chang
Nov 20, 2020·The Journal of Craniofacial Surgery·Jianqing HeQingyun Zhang

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