Operative mortality and respiratory complications after lung resection for cancer: impact of chronic obstructive pulmonary disease and time trends

The Annals of Thoracic Surgery
Marc J LickerJean-Marie Tschopp

Abstract

Smoking is a common risk factor for chronic obstructive pulmonary disease (COPD), cardiovascular disease, and lung cancer. In this observational study, we examined the impact of COPD severity and time-related changes in early outcome after lung cancer resection. Over a 15-year period, we analyzed an institutional registry including all consecutive patients undergoing surgery for lung cancer. Using the receiver-operating characteristic (ROC) curve, we analyzed the relationship between forced expiratory volume in 1 second (FEV1) and postoperative mortality and respiratory morbidity. Multiple regression analysis has also been applied to identify other risk factors. A preoperative FEV1 less than 60% was a strong predictor for respiratory complications (odds ratio [OR] = 2.7, confidence interval [CI]: 1.3 to 6.6) and 30-day mortality (OR = 1.9, CI: 1.2 to 3.9), whereas thoracic epidural analgesia was associated with lower mortality (OR = 0.4; CI: 0.2 to 0.8) and respiratory complications (OR = 0.6; CI: 0.3 to 0.9). Mortality was also related to age greater than 70 years, the presence of at least three cardiovascular risk factors, and pneumonectomy. From the period 1990 to 1994, to 2000 to 2004, we observed significant reductions in ...Continue Reading

References

Jan 1, 1975·Acta Anaesthesiologica Scandinavica. Supplementum·B Juhl, N Frost
Aug 1, 1996·The Annals of Thoracic Surgery·R J CerfolioP C Pairolero
Mar 1, 1997·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·T YanoY Ichinose
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·C WyserC T Bolliger
May 20, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·M LickerA Spiliopoulos
Jun 15, 2000·The European Respiratory Journal·M H BrutscheJ M Tschopp
Feb 24, 2001·Thorax·UNKNOWN British Thoracic Society, UNKNOWN Society of Cardiothoracic Surgeons of Great Britain and Ireland Working Party
Sep 28, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·L SantambrogioL Rosso
Sep 28, 2001·Anesthesia and Analgesia·W S BeattieP Choi
Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·P E Van Schil
Jun 12, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yasuo SekineTakehiko Fujisawa
Dec 21, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Arianne J PloegPaul J Breslau
Jan 16, 2003·Chest·Michael A BecklesUNKNOWN American College of Chest Physicians
Jun 27, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Piergiorgio SolliUgo Pastorino
Nov 7, 2003·The Annals of Thoracic Surgery·J Ryan BurkeJoseph I Miller
Nov 13, 2003·JAMA : the Journal of the American Medical Association·Brian M BlockChristopher L Wu
Jan 23, 2004·The New England Journal of Medicine·Alexander Spira, David S Ettinger
Apr 30, 2004·The Journal of Thoracic and Cardiovascular Surgery·Cliff K ChoongJoel D Cooper
May 7, 2004·The New England Journal of Medicine·Brian C Jacobson
May 18, 2005·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Pierre MagdeleinatJean-François Regnard
Jun 14, 2005·Chest·Philip A LindenDavid J Sugarbaker

❮ Previous
Next ❯

Citations

Jun 19, 2013·General Thoracic and Cardiovascular Surgery·Takuro KometaniIchiro Yoshino
May 21, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Bernd M MuehlingKarl-Heinz Orend
Dec 15, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Nuria Maria NovoaJacinto Ramos
May 3, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ryoichi KondoMakoto Kurai
Apr 13, 2013·British Journal of Anaesthesia·T JohanssonA C Sönnichsen
Nov 3, 2012·Interactive Cardiovascular and Thoracic Surgery·Philippe IcardJean-Luc Hanouz
Feb 12, 2013·Interactive Cardiovascular and Thoracic Surgery·Miguel GuerraJosé Miranda
Feb 3, 2007·Current Opinion in Oncology·Lorenzo Spaggiari, Paolo Scanagatta
May 30, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Seiichi KobayashiMasaru Yanai
Mar 10, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tomohiro HarukiShinji Fujioka
Oct 7, 2009·American Journal of Respiratory and Critical Care Medicine·Jung-Jyh HungWen-Juei Jeng
Mar 26, 2009·Critical Care : the Official Journal of the Critical Care Forum·Marc LickerJean-Marie Tschopp
Mar 29, 2011·Interactive Cardiovascular and Thoracic Surgery·Kazuhiko ShienShinichiro Miyoshi
Jan 21, 2012·The Korean Journal of Thoracic and Cardiovascular Surgery·Seong Yong ParkChang-Young Lee
Sep 21, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jae Hyun JeonJoo Hyun Kim
Jan 17, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Nuria NovoaGonzalo Varela
Oct 19, 2011·La Presse médicale·Jean-Marc Delay, Samir Jaber
Oct 12, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Lucio CaginiFrancesco Puma
May 4, 2010·World Journal of Surgery·Andreas KuehnlChristian Graeb
Jun 18, 2009·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·B MühlingL Sunder-Plassmann
Sep 21, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Emily G Teeter, Priya A Kumar
Feb 26, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Fotis VlastosNadine Szymanski
Feb 19, 2014·The Annals of Thoracic Surgery·Varun PuriBryan F Meyers
Jun 22, 2011·Revista da Associação Médica Brasileira·Eduardo Oliveira FernandesLuis Carlos Correa da Silva
Feb 2, 2013·The Annals of Thoracic Surgery·Frank DetterbeckRodolfo Morice
Oct 24, 2012·Anesthesiology Clinics·Peter Slinger, Bruce Kilpatrick
Aug 21, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y D ChengC F Zhang
Oct 1, 2011·The Annals of Thoracic Surgery·Randal S BlankJames M Jaeger
Oct 12, 2011·Surgical Oncology Clinics of North America·Lyall A Gorenstein, Joshua R Sonett
Mar 1, 2011·The Annals of Thoracic Surgery·Marc LickerCigdem Inan
Jul 14, 2010·Thoracic Surgery Clinics·Giuseppe MiserocchiIlaria Rivolta
Jun 16, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Jacek B CywinskiColleen Gorman Koch
Mar 28, 2009·The Annals of Thoracic Surgery·Farhood FarjahDouglas E Wood
May 26, 2009·The Journal of Thoracic and Cardiovascular Surgery·Marco AlifanoJean-François Régnard
Nov 21, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shawn S GrothRosemary F Kelly

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.