Operator-independent quantitative chest computed tomography versus standard assessment of interstitial lung disease related to systemic sclerosis: A multi-centric study

Modern Rheumatology
A ArianiN Sverzellati

Abstract

Interstitial lung disease (ILD) related to systemic sclerosis (SSc) is assessed with pulmonary functional tests (PFTs) and semi-quantitative scores based on extent of ILD detectable on chest computed tomography (CT). CT quantitative indexes (QCTIs) are promising tools to assess extent of ILD. This study's aim is to evaluate the validity of QCTI compared with that of chest CT standard evaluation and PFTs. Moreover, QCTI differences between patients' subgroups according to prognostic stratifications were investigated. ILD-SSc of patients from six rheumatological clinics was routinely assessed with chest CT and PFTs. Patients were clustered according to prognosis based on functional and/or radiological examinations. Finally, chest CTs were processed with OsiriX in order to obtain QCTI. Two hundred fifty-seven SSc patients were enrolled. QCTI correlation between extent of ILD and PFTs range from - 0.60 to 0.58 and from - 0.54 to 0.52, respectively. The majority of QCTI have a different distribution in patients' subgroups based on prognosis. Most of QCTI discriminate patients with an ILD severity leading to a poor prognosis. QCTI assessment of ILD-SSc is comparable to the evaluation based on chest CT and/or PFTs. QCTI values corresp...Continue Reading

References

Jan 30, 2002·Radiologic Clinics of North America·Jonathan G Goldin
Mar 29, 2003·American Journal of Respiratory and Critical Care Medicine·Athol U WellsDavid M Hansell
Nov 10, 2004·Journal of Digital Imaging·Antoine RossetOsman Ratib
Mar 31, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jan-Martin KuhnigkTobias Achenbach
Jun 28, 2005·European Journal of Radiology·Nicola SverzellatiRocco Cobelli
Jun 19, 2007·Academic Radiology·Vanessa A ZavalettaRichard A Robb
Nov 3, 2007·American Journal of Respiratory and Critical Care Medicine·Hiromitsu SumikawaNestor L Müller
Mar 29, 2008·American Journal of Respiratory and Critical Care Medicine·Nicole S L GohAthol U Wells
Jun 3, 2008·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Jiantao PuDavid S Paik
Sep 17, 2008·Rheumatology·A U WellsR Silver
Sep 23, 2008·AJR. American Journal of Roentgenology·Baskaran SundaramElla A Kazerooni
Jan 26, 2011·Physics in Medicine and Biology·Sang Cheol ParkBin Zheng
Dec 12, 2012·Radiology·Takeyuki WatadaniYukihiko Sugiyama
May 30, 2013·La Radiologia medica·Maurizio ZompatoriGian Stefano Pollini
Jul 3, 2013·Clinical Rheumatology·Gemma StricklandNeil McHugh

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Citations

May 18, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Melissa CaronRussell Steele
Nov 9, 2019·PloS One·Pablo Guisado-VascoAlarico Ariani
Jul 20, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Gianluca SambataroAlarico Ariani

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