OPG, RANK-L, bone metabolism, and BMD in patients on peritoneal dialysis and hemodialysis

Clinical Biochemistry
Eric WittersheimPierre Bergmann

Abstract

Bone turnover is regulated locally by osteoprotegerin (OPG) and receptor activator of NFkappaB ligand (RANK-L); it is not known how the circulating concentrations of these cytokines reflect renal osteodystrophy. We measured serum OPG, RANK-L, parathyroid hormone (iPTH), collagen C-terminal cross-linked telopeptide (betaCrossLaps), and bone densitometry (BMD) in 79 patients with end-stage renal disease (ESRF) undergoing dialysis. A hand X-ray of these patients was also analyzed. Controls were 65 healthy subjects. ESRF patients had high OPG and RANK-L levels; RANK-L was higher in hemodialysis than in peritoneal dialysis. OPG and RANK-L did not depend on iPTH. The bone markers were significantly increased and correlated with serum iPTH, but not with OPG or RANK-L; neither OPG nor RANK-L correlated significantly with BMD. OPG was significantly higher in patients with acro-osteolysis. OPG and RANK-L serum concentrations do not strongly reflect bone status in ESRF. However, OPG was significantly higher in patients with acro-osteolysis.

References

Jan 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Giorgio CoenErmanno Bonucci
Jun 28, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S KhoslaB L Riggs
Dec 13, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Ivica Avbersek-LuznikJanja Marc
Jun 18, 2003·Bone·S KudlacekUNKNOWN Austrian Study Group on Normative Values of Bone Metabolism
Jan 25, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ivica Avbersek-LuznikJanja Marc
Mar 19, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Olafur S IndridasonGunnar Sigurdsson

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Citations

Apr 12, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ekaterini SiomouConstantinos J Stefanidis
Aug 14, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Max D KautherChristian Wedemeyer
Oct 8, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marcello RattazziPaolo Pauletto

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