OPG/RANKL: role and therapeutic target in osteoporosis

Médecine sciences : M/S
Pierre Marie, Philippe Halbout

Abstract

Given the increasing risk of fractures with aging in western countries, there is a need for the development of safe and efficient anti-osteoporotic drugs for the prevention and treatment of osteoporosis. Recent studies have provided evidence for an essential role of RANKL (Receptor Activator of Nuclear Factor-kappa B Ligand) and its decoy receptor osteoprotegerin in the control of osteoclast differentiation and survival. Post-menopausal osteoporosis results from an imbalance between resorption and formation associated with decreased OPG/RANKL. Targeting the OPG/RANKL system may therefore have a beneficial impact in osteoporosis. Accordingly, the development of novel strategies targeting OPG/RANKL using anti-RANKL or therapeutic intervention proved to be efficient to reduce bone resorption and to prevent bone loss in postmenopausal osteoporosis. This opens the way for novel therapeutic strategies for correcting bone metabolism in various pathologic disorders characterized by increased bone remodelling and bone loss.

References

Sep 1, 2000·Science·G A Rodan, T J Martin
Feb 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P J BekkerC R Dunstan
Mar 10, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·B BolonJ Z Sheng
May 29, 2001·Current Pharmaceutical Design·P J Kostenuik, V Shalhoub
Aug 4, 2001·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·L C Hofbauer, A E Heufelder
Apr 12, 2003·Journal of Cellular Biochemistry·Rachel M LocklinB Lawrence Riggs
Apr 17, 2003·The Journal of Clinical Investigation·Guitty Eghbali-FatourechiB Lawrence Riggs
May 16, 2003·Nature·William J BoyleDavid L Lacey
Jan 30, 2004·The New England Journal of Medicine·Pierre J MeunierJean-Yves Reginster
Feb 19, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John C HuangRobert A Nissenson
Jul 29, 2004·JAMA : the Journal of the American Medical Association·Lorenz C Hofbauer, Michael Schoppet
Jan 14, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B Lawrence Riggs, A Michael Parfitt
Apr 2, 2005·The Journal of Biological Chemistry·Sheri L HolmenBart O Williams
Sep 29, 2005·Current Opinion in Pharmacology·Paul J Kostenuik
Nov 29, 2005·Endocrinology and Metabolism Clinics of North America·Sundeep Khosla, B Lawrence Riggs
Dec 17, 2005·Trends in Molecular Medicine·Teiji WadaJosef M Penninger
May 26, 2006·The New England Journal of Medicine·Ego Seeman, Pierre D Delmas
Jun 2, 2006·The New England Journal of Medicine·Julie Schwartzman, Yusuf Yazici
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuko NakamichiNaoyuki Takahashi
Sep 5, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A ClowesB L Riggs
Jul 1, 2009·British Journal of Pharmacology·T C BrennanR S Mason

❮ Previous
Next ❯

Citations

Aug 26, 2014·Molecular Endocrinology·Mohan LiuRichard M Weinshilboum
Apr 14, 2009·Médecine sciences : M/S·Anne GalloisPierre Jurdic
Jan 25, 2011·Journal of Thrombosis and Haemostasis : JTH·Z Benslimane-AhmimC Boisson-Vidal
Apr 22, 2016·British Journal of Clinical Pharmacology·Guojing LuoHongyun Lu
Dec 8, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yuanjin ChenYunxia Jiang
Mar 29, 2021·Journal of Orthopaedic Surgery and Research·Tiantian WangJianzhong Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.