Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Siyu ChenXiao Han

Abstract

Gut dysbiosis is believed to play a critical role in the pathogenesis of metabolic diseases, including obesity. Ophiopogonin D (OP-D), a steroidal glycoside and an active component extracted from the root of the plant Ophiopogon japonicus (also known as radix ophiopogonis), can regulate multiple physiologic processes. Here we show that OP-D administration reduces body weight, hyperglycemia, hyperlipidemia, and insulin resistance in male mice fed a high-fat diet (HFD). Pyrosequencing of the V4 regions of 16S rRNA genes in mouse feces revealed a deviation of the gut microbiota in response to OP-D treatment. In particular, the decreased Firmicutes-to- Bacteroidetes ratios and endotoxin-bearing Proteobacteria levels indicated that OP-D reversed HFD-induced gut dysbiosis. More importantly, the effects of OP-D on modulation of obesity and microbiota were transferable via horizontal feces transfer from OP-D-treated mice to HFD-fed mice. Taken together, our results suggest that OP-D may be used as a prebiotic agent to treat obesity-associated gut dysbiosis and metabolic syndrome.-Chen, S., Li, X., Liu, L., Liu, C., Han, X. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in ...Continue Reading

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Citations

Aug 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huai-You WangKarl W K Tsim
Sep 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mengxia TanXunhong Liu
Jul 22, 2021·Bioscience of Microbiota, Food and Health·Yan SunWen-Hui Lee
Aug 3, 2021·Frontiers in Microbiology·Qian QinSuying Ding
Jul 16, 2021·The American Journal of Chinese Medicine·Ya-Xin ZhangFeng-Hua Zhou
Dec 17, 2019·Journal of Agricultural and Food Chemistry·Joaquín Navarro Del HierroDiana Martin

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