Ophiopogonin D modulates multiple oncogenic signaling pathways, leading to suppression of proliferation and chemosensitization of human lung cancer cells

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Jong Hyun LeeKwang Seok Ahn

Abstract

Ophiopogonin D (OP-D), a steroidal glycoside obtained from the Chinese medicinal plant Ophiopogonin japonicas (the root portion), has been traditionally used to treat fever, inflammation, cough, sputum etc. However, the detailed molecular mechanism(s) underlying its therapeutic actions is still unknown. Because nuclear factor-κB (NF-κB), PI3K/AKT, and activator protein-1 (AP-1) signaling cascades have significant functions in cell proliferation, inflammation, and angiogenesis in tumor cells, we hypothesized that OP-D may disrupt these signaling cascades to exert its anticancer effects in human lung-cancer cells. We evaluated the effect of OP-D on multiple signaling cascades and its regulated functional responses in lung cancer cells. OP-D blocked both basal and cytokine-induced proliferation of human lung-cancer cells and caused down-regulation of the expression of diverse oncogenic gene products through the suppression of NF-κB, PI3K/AKT, and AP-1 pathways; but did not affect JNK, p38 and ERK MAP kinases. Interestingly, OP-D suppressed constitutive NF-κB activation in lung cancer cells via interfering with the IκB kinase activation, which inhibited phosphorylation and caused degradation of IκB-α. OP-D also blocked phosphorylat...Continue Reading

Citations

May 6, 2019·Cancers·Samantha Kah Ling OngAnupam Bishayee
Jun 30, 2019·Biomolecules·Nand Kishor RoyAjaikumar B Kunnumakkara
Mar 15, 2019·Current Molecular Medicine·Arife ZeybekMehmet Emin Erdal
Apr 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min Hee YangKwang Seok Ahn
Jul 25, 2019·Biomedicines·Myriam MerarchiKwang Seok Ahn
Jan 3, 2020·International Journal of Oncology·Zongliang LuHongxia Xu
Aug 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Young Yun JungKwang Seok Ahn
May 3, 2020·Cellular and Molecular Life Sciences : CMLS·Anuradha KirtoniaManoj Garg
Oct 1, 2020·Biomolecules·Ebrahim Rahmani MoghadamAlan Prem Kumar
Aug 21, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Xue ZhuYu Chen
Jun 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Milad AshrafizadehSaeed Samarghandian
Sep 25, 2021·The Journal of Pharmacy and Pharmacology·Min Hee YangKwang Seok Ahn

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