Ophiosphaerellins A-I, Polyketide-Derived Compounds from the Endolichenic Fungus Ophiosphaerella korrae

ACS Omega
Yuelan LiHong-Xiang Lou

Abstract

Ophiosphaerellins A-I (1-9), the first example of bicyclo[4.1.0]heptenones, as well as their biosynthetic relatives ophiosphaerekorrins A-B (10-11) were isolated from the endolichenic fungus Ophiosphaerella korrae. Biosynthetically, they were derived from the polyketide pathway, and their absolute configurations were determined on the basis of the combination analysis of spectral data, circular dichroism calculations, and single-crystal X-ray diffraction measurement. Preliminary test with thin-layer chromatography bioautography found that this type of compounds showed moderate acetylcholinesterase (AChE) inhibitory effects.

References

Jan 10, 1997·The Journal of Biological Chemistry·W EisenreichA Bacher
Sep 1, 1999·Natural Product Reports·B J Rawlings
Apr 28, 2011·Applied Microbiology and Biotechnology·Amal Hassan AlyPeter Proksch
Sep 12, 2015·Journal of Natural Products·Xiao-Bin LiHong-Xiang Lou
Aug 25, 2016·Journal of Natural Products·Yan-Hui ZhouHong-Xiang Lou
Aug 25, 2016·Journal of Natural Products·Wei LiHong-Xiang Lou
Mar 14, 2017·Toxicology and Applied Pharmacology·Ming ZhangHongxiang Lou
Apr 2, 2017·Trends in Biotechnology·Brahma N SinghYueming Jiang

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Citations

Mar 14, 2018·Natural Product Reports·Robert A Hill, Andrew Sutherland
May 13, 2020·Journal of Natural Products·Fei XieHong-Xiang Lou
Aug 24, 2018·Journal of Natural Products·Ke XuHong-Xiang Lou
Jan 11, 2022·Natural Product Research·Jintong SongHongxiang Lou

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Methods Mentioned

BETA
X-ray
circular dichroism
NMR

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