Ophthalmic corticosteroids in pregnant women with allergic conjunctivitis and adverse neonatal outcomes: propensity score analyses

American Journal of Ophthalmology
Yohei HashimotoMakoto Aihara

Abstract

The risks of topical ophthalmic corticosteroids during pregnancy remain unclear. We investigated the association between exposure to topical ophthalmic corticosteroids during pregnancy and adverse neonatal outcomes. Retrospective, cohort, database study. Pregnant women with allergic conjunctivitis in the JMDC Claims Database (JMDC Inc., Japan) between 2005 and 2018 were included. We compared adverse neonatal outcomes (congenital anomalies [CA], preterm birth [PB], low birthweight [LB], and the composite outcome of these three) between mothers with and withouttopical ophthalmic corticosteroids during the first trimester. Controls were women who were not prescribed topical ophthalmic corticosteroids during the first trimester. We first calculated propensity scores with known confounders, including disorders during pregnancy, other chronic comorbidities, and use of antihistamines. We then conducted logistic regression with propensity-score adjustment. We identified 6847 eligible women of whom 898 (13%) had received topical ophthalmic corticosteroids. CA occurred in 5.5% and 4.9%, PB in 3.4% and 3.9%, LB in 5.9% and 7.0%, and the composite outcome in 11.7% and 11.7% of exposed and unexposed mothers, respectively. Corticosteroid eye...Continue Reading

Citations

Nov 14, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Daisuke ShigemiHideo Yasunaga
Jun 12, 2021·The Journal of Investigative Dermatology·Megumi MizawaUNKNOWN Japan Environment and Children’s Study Group
Jul 21, 2021·Human Fertility : Journal of the British Fertility Society·Daisuke ShigemiHideo Yasunaga
Aug 10, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ai KidoKoji Kawakami

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