Abstract
To investigate whether different types of ocular manifestations are associated with congenital heart disease (CHD) in a large Caucasian population of children and young adults with Down syndrome (DS). Population-based, case-control study which included 185 subjects with DS (mean age 13.2 ± 7.9 years), who reported presence or absence of CHD; DS with CHD group (51 subjects, mean age 10.6 ± 5.6 years) and DS without CHD (134 subjects, mean age 14.2 ± 8.4 years). In our sample with DS and CHD, strabismus was found in 15 subjects (29.4%), nystagmus in 1 (2.0%), epiblepharon in 21 (41.2%) and Brushfield spots in 15 (31.3%). In the DS without CHD group, strabismus was found in 38 participants (28.4%), nystagmus in 13 (9.7%), epiblepharon in 31 (23.5%) and Brushfield spots in 21 (16.0%). Only the variables epiblepharon and presence of Brushfield spots differed significantly between the two groups (p = 0.02 and p = 0.03, respectively). Hyperopia was present in 26 participants (53.1%) in the DS with CHD group, and in 65 (57.0%) in the DS without CHD group. Oblique astigmatism was present in 25 (52.1%) in the DS with CHD group and in 61 (53.5%) in the DS without CHD group. Frequencies of DS participants presenting with strabismus, nystag...Continue Reading
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Citations
Dec 14, 2019·Strabismus·Ali MakatebSoheila Asgari
Oct 2, 2020·The British and Irish Orthoptic Journal·Alia HarrisonAnna O'Connor
Apr 13, 2020·Surgical and Radiologic Anatomy : SRA·Marissa L Fernández-de-LunaJesus Mohamed-Hamsho
Jul 30, 2021·Eye and Brain·Lavinia PostolacheSophie Lhoir
Oct 8, 2021·Investigative Ophthalmology & Visual Science·Laura L JohnsonLinda K McLoon