Ophthalmic manifestations of immune reconstitution inflammatory syndrome associated with Cryptococcus neoformans

Ocular Immunology and Inflammation
Rahul N KhuranaNarsing Rao

Abstract

To describe the ophthalmic manifestations of immune reconstitution inflammatory syndrome (IRIS) associated with Cryptococcus neoformans. Four HIV-positive patients on highly active anti-retroviral therapy (HAART) presented with marked optic disk swelling. Three months after the episode of IRIS, 2 of the patients maintained 20/20 visual acuity whose elevated intracranial pressure (ICP) was successfully managed, while 2 patients visual acuities were worse than 20/400 whose ICP was persistently elevated. Cryptococcus is another opportunistic infectious organism associated with IRIS with ophthalmic manifestations. Ophthalmologists have the opportunity to play a key role in the early diagnosis and management to prevent serious visual loss.

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Citations

Sep 21, 2013·ISRN AIDS·Spinello Antinori
Jul 10, 2009·Current Opinion in Infectious Diseases·Derek J SloanDavid G Lalloo
Dec 18, 2012·Current Opinion in Infectious Diseases·Nicky LongleyJoseph N Jarvis
May 13, 2020·Ocular Immunology and Inflammation·Remco P H PetersJohn H Kempen
Jan 8, 2013·AIDS·Debbie LaaksDavid Meyer
Oct 17, 2009·Ocular Immunology and Inflammation·Julia ShulmanVeeraf Sanjana

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