PMID: 8583378Sep 1, 1995Paper

Ophthalmic preservatives as absorption promoters for ocular drug delivery

The Journal of Pharmacy and Pharmacology
H SasakiJ Nakamura

Abstract

The effects of ophthalmic preservatives on the drug permeability through isolated ocular membranes of albino rabbits were investigated using a two-chamber glass diffusion cell. Tilisolol and fluorescein isothiocyanate (FITC)-dextrans (average molecular weights 4400 and 9400 Da; FD-4 and FD-10, respectively) were used as model penetrants of ophthalmic beta-blockers and peptide drugs. Preservatives significantly enhanced the corneal penetration of not only tilisolol but also FITC-dextrans. Especially, benzalkonium chloride increased the corneal permeability of FD-4 and FD-10 by 28.8 and 37.1 times, respectively. These results indicate the usefulness of ophthalmic preservatives as absorption promoters for the ocular delivery of beta-blockers and hydrophilic macromolecules. Preservatives also enhanced the conjunctival permeability of tilisolol, FD-4 and FD-10. The promoting effect of preservatives on the conjunctival drug penetration was smaller than that on the corneal one. Preservative increased the ratio of corneal to conjunctival permeability of tilisolol, FD-4 and FD-10. The different responses of corneal and conjunctival drug penetrations to ophthalmic preservatives may be useful to control the extent and pathway for the ocul...Continue Reading

References

Mar 1, 1978·American Journal of Ophthalmology·M G DoaneC H Dohlman
Jun 1, 1975·Acta Ophthalmologica·K Green, A M Tonjum
Apr 1, 1990·Clinical Pharmacokinetics·R D Schoenwald
Oct 1, 1989·Journal of Pharmaceutical Sciences·G C Chiou, C Y Chuang
Jan 1, 1986·Journal of Ocular Pharmacology·V H Lee, J R Robinson
Apr 1, 1985·Current Eye Research·S D Klyce, C E Crosson
Jan 1, 1971·Experimental Eye Research·R J Marsh, D M Maurice
Nov 1, 1971·American Journal of Ophthalmology·K Green, A Tonjum
Nov 1, 1983·Journal of Pharmaceutical Sciences·R D Schoenwald, H S Huang
Nov 1, 1983·Journal of Pharmaceutical Sciences·H S HuangJ L Lach
Jan 1, 1982·Survey of Ophthalmology·J W Shell

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Citations

Mar 17, 2004·International Journal of Pharmaceutics·Masayo HigashiyamaKakuji Tojo
Oct 31, 1998·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·K MorimotoY Nakai
Apr 27, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pascal FurrerRobert Gurny
May 2, 2002·Clinical and Experimental Immunology·M A ThielK A Williams
Sep 12, 2002·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Andrew A AcheampongDiane Tang-Liu
Nov 7, 2002·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Martina ScholzSigrid Keipert
Aug 24, 2004·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jennifer Q DongScott M Whitcup
Dec 4, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Makoto AiharaShoichi Sawaguchi
Mar 1, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Xianggen WuTing Liu
Jul 17, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ramesh SrirangamSoumyajit Majumdar
Dec 7, 2007·Biological & Pharmaceutical Bulletin·Tadahiro NakamuraHitoshi Sasaki
Jul 11, 2006·Expert Opinion on Drug Delivery·Soumyajit Majumdar, Ashim K Mitra
Jul 9, 2002·Drug Development and Industrial Pharmacy·Indu Pal Kaur, Meenakshi Kanwar
Feb 5, 2013·International Journal of Pharmaceutics·Jike SongDamei Liu
Jan 15, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Neil S SharmaVictor S C Fung
Jan 25, 2005·International Journal of Pharmaceutics·Takayuki KikuchiHitoshi Sasaki
Jun 13, 2006·Journal of Cataract and Refractive Surgery·Michael G HaasThomas E Davis
Jun 7, 2002·AAPS PharmSci·Pascal FurrerRobert Gurny
Jun 23, 2005·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ulrich BeckerClaus-Michael Lehr
Feb 20, 2010·Journal of Refractive Surgery·Antonio Leccisotti, Tahmina Islam
Jan 1, 1996·Drug Delivery·T L Whateley

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