Ophthalmological outcomes of patients treated for pineal region tumors

Journal of Neurosurgery. Pediatrics
Elizabeth V HankinsonDavid D Cochrane

Abstract

OBJECTIVE The ophthalmological outcomes of children treated for pineal tumors have received limited attention in the literature. METHODS This paper reviews the outcomes of 29 children treated for pineal and posterior third ventricular tumors in the contemporary era using chemotherapy, radiotherapy, and resection as defined by the histology and/or marker profile of the tumor. RESULTS At the time of diagnosis, all patients except 1 had hydrocephalus and all had ophthalmological involvement. Papilledema was found in 69% of patients. Seventy-five percent of patients had partial or complete Parinaud's syndrome, and diplopia or blurred vision was noted in the remaining patients. Visual acuity was impaired in 8 patients. Outcomes were dependent on the histology of the tumor and the treatment required. Those patients who did not requiring resection showed a lower rate of ophthalmological worsening during treatment and greater long-term improvement, in particular with respect to up-gaze palsy. Patients who underwent resection for postchemotherapy residual disease or primary resection showed greater worsening during treatment and lesser degrees of recovery. All patients with impaired visual acuity improved with treatment. CONCLUSIONS As ...Continue Reading

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Citations

Jun 28, 2017·Acta Neurologica Scandinavica·L PollakR Huna-Baron
Jun 22, 2018·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·N K SerovaG V Danilov
Sep 22, 2018·International Ophthalmology Clinics·Jason H Peragallo
Dec 6, 2018·Current Opinion in Neurology·Jason H Peragallo
Aug 12, 2020·Vestnik oftalmologii·N K SerovaE I Butenko
Jan 27, 2019·Neuroradiology·Amrita-Amanda D VuppalaDavid M Yousem
Feb 10, 2021·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·N K SerovaYu Yu Trunin
Oct 24, 2020·Surgical Neurology International·Ricardo Malcata NogueiraManuela Mafra
Sep 2, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Jonah E YousifJonathan D Trobe
Feb 8, 2020·Journal of Neurosurgery·Hirokazu TakamiDavid J Daniels

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Methods Mentioned

BETA
biopsy
surgical resection

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