PMID: 3773354Mar 1, 1986Paper

Opiate-antagonist reversal of neurological deficits--experimental and clinical studies

The Japanese Journal of Psychiatry and Neurology
S NambaT Masaoka

Abstract

The proximal left M1 and the common trunk of A2 were clipped in 12 adult dogs. Naloxone was injected after placing the clips onto 6 dogs. Neither the systemic blood pressure nor the local cerebral blood flow were influenced by naloxone. In another group of 6 dogs with chronic right hemiplegia, naloxone proved passably effective in improving the hemiplegia. Eight patients with neurological deficits of various etiologies were administered levallorphan. The improvement in motor performance and/or elevation of mental activity was observed more or less in all but 2 of the patients. It was considered that the effect of opiate antagonists is based partially on the facilitation of synaptic transmission exaggerated by the arousal response.

References

Jul 20, 1979·Science·A I Faden, J W Holaday
Jul 1, 1984·Stroke; a Journal of Cerebral Circulation·R J FallisR A Lobo
Aug 8, 1981·Lancet·D S Baskin, Y Hosobuchi
May 29, 1982·Lancet·J W Holaday, R J D'Amato
Sep 11, 1982·Lancet·J Y BousigueM Trémoulet
May 1, 1984·Stroke; a Journal of Cerebral Circulation·A I Faden
Mar 1, 1983·Stroke; a Journal of Cerebral Circulation·A I Faden
Nov 1, 1983·Neurology·J R CutlerR P Simon
Sep 1, 1982·Surgical Neurology·O Sugar

❮ Previous
Next ❯

Citations

Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Lise A Labiche, James C Grotta
Sep 1, 1996·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·P Lyden
Apr 2, 2008·Expert Opinion on Pharmacotherapy·K JeyaseelanA Armugam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.