PMID: 3768692Sep 24, 1986Paper

Opiate microinjections into midbrain do not affect the aversiveness of caudal trigeminal stimulation but produce somatotopically organized peripheral hypoalgesia

Brain Research
G S Kasman, J P Rosenfeld

Abstract

High-dose microinjections of morphine sulfate (15 micrograms) and (D-Ala2)-Met-enkephalin (30 micrograms) were made into the ventral periaqueductal gray of rats. Consistent with previous reports using lower doses, both opiates produced hypoalgesia for noxious thermal stimuli applied to the upper and lower body. More hypoalgesia was observed on the face than on the hind legs or tail. Current thresholds of aversive reaction to stimulation in the trigeminal subnucleus caudalis were unaffected by microinjection of either opiate. Systemic injections of 6 mg/kg morphine sulfate profoundly inhibited defense responses to peripheral noxious stimuli and significantly elevated aversive reaction thresholds for stimulation in the trigeminal subnucleus caudalis. Aversive reactions to stimulation in the dorsal periaqueductal gray remained unaffected by either microinjected or systemically administered opiates.

References

Aug 1, 1977·Pain·Donald D Price, Ronald Dubner
Apr 25, 1975·Brain Research·J P Rosenfeld, R Kowatch
Jun 25, 1976·Science·T L Yaksh, T A Rudy

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Citations

Jan 1, 1997·Acta Anaesthesiologica Scandinavica·T L Yaksh
May 12, 2011·Journal of Pain Research·Claudia DomnickMichael Hauck
Sep 9, 2016·Journal of Neurophysiology·Nabil El BitarDaniel Le Bars

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