Abstract
Functional MRI (fMRI) was employed to determine whether repeated heroin self-administration (SA) produces tolerance or sensitization in the brain of heroin-SA rats. Twelve rats were evenly divided into saline and heroin (0.06 mg/kg, 4 hr/day) SA groups. There was a progressive increase in drug-SA behavior and daily heroin intake during the 8-9 days of heroin-SA training. Within 24 hr after the last session of daily SA, acute heroin (0.1 mg/kg) administration induced regional blood oxygen level-dependent (BOLD) signals in both groups of rats. The positive BOLD signals appeared mainly in the cortical regions, including the prefrontal cortex, cingulate, and olfactory cortex, while the negative BOLD signals were predominantly located in subcortical regions such as caudate and putamen, nucleus accumbens, thalamus, and hypothalamus. However, the number of activated voxels or BOLD-signal intensity was significantly less in heroin-SA rat in regions of prefrontal cortex, nucleus accumbens, and thalamus, etc., compared to the changes in the saline control rats. Application of gamma-vinyl GABA (100 mg/kg), an irreversible GABA-transaminase inhibitor, failed to block opiate actions in the heroin-SA rats. Together, these data suggest that r...Continue Reading
References
Oct 20, 1992·European Journal of Pharmacology·Z L RossettiG L Gessa
Mar 1, 1991·Epilepsia·T HalonenP J Riekkinen
Aug 1, 1990·The Journal of Physiology·Z Z PanP B Osborne
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·C A Dackis, M S Gold
Jun 1, 1986·Brain Research·T E Robinson, J B Becker
Jul 5, 1985·JAMA : the Journal of the American Medical Association·M A Bozarth, R A Wise
Oct 1, 1983·Neuropharmacology·M BartolettiM Babbini
Apr 1, 1996·Current Opinion in Neurobiology·R A Wise
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Dec 1, 1995·Synapse·D W SelfE J Nestler
Nov 1, 1996·Neurochemical Research·G Schulteis, G F Koob
Apr 18, 1997·Brain Research·J Y ChangD J Woodward
Oct 23, 1997·Neuron·H C BreiterS E Hyman
Dec 24, 1997·Nature·C W VaughanM J Christie
Aug 12, 1998·The American Journal of Psychiatry·E A SteinA S Bloom
Aug 26, 1998·Drug and Alcohol Dependence·F J White, P W Kalivas
Dec 24, 1998·Peptides·L M HarrisonJ E Zadina
Apr 2, 1999·The European Journal of Neuroscience·L A SellR J Dolan
Jun 25, 1999·Synapse·R S LeeS J Henriksen
Oct 16, 1999·Brain Research. Molecular Brain Research·M Erdtmann-VourliotisV Höllt
Mar 29, 2000·Progress in Brain Research·H L Fields
May 3, 2000·Neuroreport·H XuE A Stein
Sep 6, 2000·Psychopharmacology·L J Vanderschuren, P W Kalivas
Mar 17, 2001·Nature Reviews. Neuroscience·E J Nestler
Apr 11, 2001·Drug and Alcohol Dependence·G Winger, J H Woods
Jul 13, 2001·Nature·J W GrimmY Shaham
Jul 31, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T MuegglerM Rudin
Nov 6, 2001·Nature Neuroscience·M J ThomasR C Malenka
Dec 26, 2001·Brain Research·M A F M GerritsJ M van Ree
Aug 20, 2002·Annual Review of Psychology·Terry E Robinson, Kent C Berridge
Sep 10, 2002·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Zheng-Xiong Xi, Elliot A Stein
Oct 24, 2002·Behavioural Pharmacology·N D VolkowG-J Wang
Nov 6, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zheng-Xiong XiShi-Jiang Li
Jan 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Feng LuoShi-Jiang Li
Feb 13, 2003·The European Journal of Neuroscience·Agustin ZapataBeatriz A Rocha
Citations
Mar 22, 2005·Psychopharmacology·C A StewardY B Shah
Feb 3, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Scott A ChenGeorge F Koob
Jun 19, 2010·Brain : a Journal of Neurology·Jaymin UpadhyayDavid Borsook
Jan 13, 2009·Journal of Psychiatric Research·Feng LuoCraig F Ferris
Nov 26, 2008·European Journal of Pharmacology·Gary B KaplanWenying Fan
Jul 5, 2011·Journal of Neuroendocrinology·M Febo
Feb 22, 2005·Current Opinion in Biotechnology·J Michael TyszkaRussell E Jacobs
Aug 29, 2006·Journal of Neuroscience Methods·Adam J SchwarzAngelo Bifone
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Apr 13, 2012·NeuroImage·Bruce G Jenkins
Mar 13, 2014·Drug and Alcohol Dependence·Meenu Minhas, Francesco Leri
Sep 28, 2006·Neurochemical Research·Yun XiangHao Lei
May 28, 2017·Journal of Molecular Histology·Belin G TeklezgiThavendran Govender
Nov 20, 2016·Frontiers in Neuroscience·Kelsey MooreCraig F Ferris
Feb 12, 2021·Molecular Pain·Kyle MurrayPaul Geha