Opiate withdrawal induces dynamic expressions of AMPA receptors and its regulatory molecule CaMKIIalpha in hippocampal synapses

Life Sciences
Weixia ZhongJianhong Luo

Abstract

Adaptive changes in brain areas following drug withdrawal are believed to contribute to drug seeking and relapse. Cocaine withdrawal alters the expression of GluR1 and GluR2/3 subunits of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors in nucleus accumbens or amygdala, but the influence of drug withdrawal on hippocampus is little known. Here, we have examined the expression of GluR1 and GluR2/3 in hippocampal membrane and synaptic fractions following repeated morphine exposure and subsequent withdrawal. Repeated morphine exposure for 12 d increased GluR1 and GluR2/3 in synaptosome but not in membrane fraction. Interestingly, CaMKIIalpha, known to be able to regulate the function of AMPA receptors, was decreased in synaptosome but not in membrane fraction; pCaMKIIalpha, the phosphorylated form of CaMKIIalpha, was increased in both fractions. However, during opiate withdrawal, GluR1 was generally reduced while GluR2/3 was prominently increased in both fractions; pCaMKIIalpha was strongly decreased immediately after withdrawal, but detectably increased in late phase of morphine withdrawal in both fractions. Importantly, the opiate withdrawal-induced increase in GluR2/3 was dependent on the activation of g...Continue Reading

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Citations

Aug 2, 2008·Clinical and Experimental Pharmacology & Physiology·Zargham SepehrizadehMousa Sahebgharani
Mar 3, 2007·The European Journal of Neuroscience·Mauricio Valenzuela-HarringtonJosé M Delgado-García
Nov 3, 2016·Iranian Journal of Psychiatry and Behavioral Sciences·Bahareh AminAzadeh Mesripour
Jan 13, 2017·PloS One·Vincenzo MatteiRoberta Misasi
Nov 21, 2009·Drug and Alcohol Dependence·Melinda E LullKent E Vrana
Nov 11, 2008·Annals of the New York Academy of Sciences·Anna M Lee, Robert O Messing
May 11, 2012·The Journal of Pharmacy and Pharmacology·Jannike M AndersenJørg Mørland
Jan 1, 2008·Substance Abuse : Research and Treatment·Kara L Kuntz-MelcavageKent E Vrana

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