Opiate withdrawal induces Narp in the extended amygdala

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Irving M Reti, Jay M Baraban

Abstract

The negative affective states associated with drug withdrawal produce long-lasting behavioral effects thought to play a central role in the development and maintenance of dependence. However, little is known about the molecular mechanisms mediating the long-term effects of drug withdrawal. Neuronal activity-regulated pentraxin (Narp) is a secreted neuronal immediate early gene (IEG) product that regulates AMPA receptor clustering at synapses. As both IEGs and changes in AMPA receptor trafficking mediate enduring forms of neuronal plasticity, we have assessed whether Narp could be involved in the molecular adaptations accompanying drug withdrawal. To this end, we checked the effect of opiate withdrawal on Narp expression in the extended amygdala, a brain region closely linked to the aversive effects of drug withdrawal. We found a marked increase in the number of Narp-positive cells in this region following opiate withdrawal triggered by either low doses of opiate antagonists or by 'natural withdrawal', removal of the morphine pellets used to induce dependence. In contrast, Arc, another 'effector' IEG, was not induced by opiate withdrawal. As expected, pretreatment of animals with clonidine, which blocks opiate withdrawal, suppre...Continue Reading

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Citations

Aug 30, 2008·Behavioral Neuroscience·Irving M RetiJay M Baraban
Jun 10, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hans S CrombagIrving M Reti
Jul 11, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marco CecchiHuda Akil
Jan 1, 2011·ILAR Journal·Irving M RetiJay M Baraban
Dec 7, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander W JohnsonIrving M Reti
Dec 2, 2004·Peptides·Richard J Bodnar, Gad E Klein
Oct 15, 2013·Behavioural Brain Research·Ashley M BlouinIrving M Reti
May 25, 2016·Neuroscience and Biobehavioral Reviews·Meg Waraczynski
Oct 21, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrew D ChangIrving M Reti
Aug 20, 2005·Addiction Biology·Makoto FukumotoRyuzou Kawahara
Sep 25, 2020·Translational Psychiatry·Katherine E OdegaardGurudutt Pendyala
Mar 31, 2021·Experimental Neurology·Tao WangShuanglin Hao

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