Opioid and orexin hedonic hotspots in rat orbitofrontal cortex and insula

Proceedings of the National Academy of Sciences of the United States of America
Daniel C Castro, K C Berridge

Abstract

Hedonic hotspots are brain sites where particular neurochemical stimulations causally amplify the hedonic impact of sensory rewards, such as "liking" for sweetness. Here, we report the mapping of two hedonic hotspots in cortex, where mu opioid or orexin stimulations enhance the hedonic impact of sucrose taste. One hedonic hotspot was found in anterior orbitofrontal cortex (OFC), and another was found in posterior insula. A suppressive hedonic coldspot was also found in the form of an intervening strip stretching from the posterior OFC through the anterior and middle insula, bracketed by the two cortical hotspots. Opioid/orexin stimulations in either cortical hotspot activated Fos throughout a distributed "hedonic circuit" involving cortical and subcortical structures. Conversely, cortical coldspot stimulation activated circuitry for "hedonic suppression." Finally, food intake was increased by stimulations at several prefrontal cortical sites, indicating that the anatomical substrates in cortex for enhancing the motivation to eat are discriminable from those for hedonic impact.

References

Aug 1, 1987·The Journal of Comparative Neurology·D F Cechetto, C B Saper
Aug 1, 1972·Behavioral Biology·A Routtenberg, M Sloan
Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
Aug 1, 1982·Journal of Comparative and Physiological Psychology·C R Wirsig, H J Grill
Sep 19, 1998·The Journal of Comparative Neurology·C J Shi, M D Cassell
May 5, 1999·Nature·L Tremblay, W Schultz
Feb 13, 2001·Neuroscience and Biobehavioral Reviews·J E SteinerK C Berridge
Aug 28, 2001·Brain : a Journal of Neurology·D M SmallM Jones-Gotman
Aug 13, 2003·The European Journal of Neuroscience·Edmund T RollsIvan E T de Araujo
Oct 17, 2003·Journal of Personality and Social Psychology·Jennifer S BeerRobert T Knight
Jun 1, 1952·Brain : a Journal of Neurology·W R HESSD A McDONALD
Feb 21, 2004·Science·Tor D WagerJonathan D Cohen
May 26, 2004·Progress in Neurobiology·Morten L Kringelbach, Edmund T Rolls
Jun 28, 2005·Brain Research·A J Thorpe, C M Kotz
Sep 2, 2005·Nature Reviews. Neuroscience·Morten L Kringelbach
Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kyle S Smith, Kent C Berridge
Dec 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Susana Peciña, Kent C Berridge
Feb 7, 2006·Physiology & Behavior·Michael RomerLaurent Brondel
Feb 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kyle S Smith, Kent C Berridge
Apr 5, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephen V MahlerKent C Berridge
Jun 8, 2007·The European Journal of Neuroscience·Andrew J CalderAndrew D Lawrence
Jul 1, 2008·The European Journal of Neuroscience·David Mataix-ColsMary L Phillips
Jul 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexis FaureKent C Berridge
Nov 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jonathan A HollanderPaul J Kenny
Sep 15, 2009·Brain Research·Craig W BerridgeNicole M Vittoz
Sep 19, 2009·Journal of Clinical and Experimental Neuropsychology·Justin S FeinsteinDaniel Tranel
Oct 12, 2010·Physiology & Behavior·H PinosP Collado
Mar 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jesus D MenaBrian A Baldo
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kyle S SmithJ Wayne Aldridge
Nov 22, 2011·Nature Neuroscience·Jonathan D Wallis
Jan 11, 2012·Progress in Brain Research·Rudolf Nieuwenhuys
Sep 18, 2012·Biological Psychiatry·Jocelyn M Richard, Kent C Berridge
Mar 7, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chao-Yi Ho, Kent C Berridge
Jan 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Lindsey A SchierAlan C Spector

❮ Previous
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Citations

Jul 28, 2018·Journal of Neuroscience Research·Pierre-Eric LutzRaffaella Calati
Aug 1, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Sofia Uribe-CerdaClaudio Perez-Leighton
Nov 5, 2019·Rheumatology·S Mechiel Korte, Rainer H Straub
Dec 25, 2019·The Journal of Comparative Neurology·Nanette Y SchneiderJean Gascuel
Dec 15, 2019·Cognitive, Affective & Behavioral Neuroscience·Hammad A KhanKent C Berridge
Aug 29, 2019·Nature Neuroscience·Daniel A GehrlachNadine Gogolla
Apr 10, 2019·Cognitive, Affective & Behavioral Neuroscience·Henk van SteenbergenSiri Leknes
Jun 3, 2020·Nature Communications·Shelley M WarlowKent C Berridge
Aug 28, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J ChenM Peciña
Sep 25, 2018·Frontiers in Psychology·Kent C Berridge
Feb 6, 2019·Nature Reviews. Neuroscience·Kent C Berridge
Jun 1, 2019·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Xinhe LiuFei Luo
May 10, 2020·Cerebral Cortex·Fillan GradyJoel C Geerling
Nov 28, 2020·Cellular and Molecular Neurobiology·Cherkaouia KibalyCatherine M Cahill
Aug 28, 2020·Physiology & Behavior·Ileana Morales, Kent C Berridge
Dec 29, 2020·Neuroscience and Biobehavioral Reviews·Isabell M MeierDavid Terburg
Sep 13, 2020·Trends in Cognitive Sciences·James H KryklywyRebecca M Todd
Dec 6, 2019·Peptides·Richard J Bodnar
Jan 10, 2021·Neuroscience and Biobehavioral Reviews·Jiří Dvořáček, Dalibor Kodrík
Feb 4, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pierre-Eric LutzGustavo Turecki
Mar 7, 2020·Neuropharmacology·Shi-Bin Li, Luis de Lecea
Feb 26, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shijing WangSakina J Rizvi
Mar 9, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Marta PeciñaAlexandre Y Dombrovski
Apr 30, 2021·Drug and Alcohol Dependence·Guangfei LiChiang-Shan R Li
May 6, 2021·Neuroscience and Biobehavioral Reviews·Sakina J RizviTim Salomons
Jul 19, 2021·Psychiatry Research. Neuroimaging·Gereon Johannes SchnellbächerMikhail Votinov
Aug 26, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Brian A Baldo, Kent C Berridge
Aug 29, 2021·Translational Psychiatry·Tatu KantonenLauri Nummenmaa
Aug 31, 2021·Neuropharmacology·Samuel W CentanniFrederic W Hopf
Jul 7, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Juliana L GiacominiBrian A Baldo
Dec 28, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Paul Cisek

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